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“弱A”血型表型。红细胞凝集性与抗原位点密度之间的关系。

'Weak A' phenotypes. Relationship between red cell agglutinability and antigen site density.

作者信息

Cartron J P, Gerbal A, Hughes-Jones N C, Salmon C

出版信息

Immunology. 1974 Oct;27(4):723-7.

PMID:4435836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445712/
Abstract

Thirty-five weak A samples including fourteen A, eight A, seven A, three A and three A were studied in order to determine their A antigen site density, using an IgG anti-A labelled with I. The values obtained ranged between 30,000 A antigen sites for A individuals, and 700 sites for the A red cells. The hierarchy of values observed made it possible to establish a quantitative relationship between the red cell agglutinability of these phenotypes measured under standard conditions, and their antigen site density.

摘要

为了确定35份弱A样本的A抗原位点密度,使用用碘标记的IgG抗A对其中的14份A、8份A、7份A、3份A和3份A进行了研究。得到的值在A个体的30,000个A抗原位点到A红细胞的700个位点之间。观察到的值的层次结构使得能够在标准条件下测量的这些表型的红细胞凝集性与其抗原位点密度之间建立定量关系。

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Immunology. 1974 Oct;27(4):723-7.
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本文引用的文献

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SOURCES OF QUANTITATIVE VARIATION OF THE HUMAN A ANTIGEN OF ERYTHROCYTES.红细胞人A抗原定量变异的来源
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EFFICIENT LABELLING OF SERUM PROTEINS WITH I-131 USING CHLORAMINE T.使用氯胺T用I-131对血清蛋白进行高效标记
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REACTION OF 7S AND 19S COMPONENTS OF IMMUNE RABBIT ANTISERA WITH HUMAN GROUP A AND AB RED CELLS.免疫兔抗血清的7S和19S成分与人A组及AB型红细胞的反应
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Antigen- and antibody-combining properties and their influence on the immune reaction of red cells.抗原与抗体的结合特性及其对红细胞免疫反应的影响。
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Quantitative measurements concerning A and B antigen sites.关于A和B抗原位点的定量测量。
Vox Sang. 1967 May;12(5):321-8. doi: 10.1111/j.1423-0410.1967.tb03362.x.
7
The significance of erythrocyte antigen site density. I. Hemagglutination.红细胞抗原位点密度的意义。I. 血凝反应
J Clin Invest. 1970 Jan;49(1):87-95. doi: 10.1172/JCI106226.
8
Demonstration of ferritin-labelled antibodies bound to human erythrocytes fixed with glutaraldehyde.铁蛋白标记的抗体与经戊二醛固定的人红细胞结合的展示。
Vox Sang. 1972;22(6):549-53. doi: 10.1111/j.1423-0410.1972.tb04645.x.
9
Observations on the reactions between D-positive red cells and ( 125 I)IgM anti-D molecules and subunits.关于D阳性红细胞与(125I)IgM抗-D分子及亚基之间反应的观察
Immunology. 1971 Sep;21(3):499-507.
10
Qualitative differences in the N-acetyl-D-galactosaminyltransferases produced by human A1 and A2 genes.人类A1和A2基因产生的N-乙酰-D-半乳糖胺基转移酶的定性差异。
Proc Natl Acad Sci U S A. 1973 Jan;70(1):220-4. doi: 10.1073/pnas.70.1.220.