N-甲基-N-亚硝基脲的致癌性：DNA中O6-甲基鸟嘌呤切除修复的可能作用。 - Suppr

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超能文献

Carcinogenicity of N-methyl-N-nitrosourea: possible role of excision repair of O6-methylguanine from DNA.

作者信息

Kleihues P, Margison G P

出版信息

J Natl Cancer Inst. 1974 Dec;53(6):1839-41.

PMID:4436874

Abstract

摘要

相似文献

Carcinogenicity of N-methyl-N-nitrosourea: possible role of excision repair of O6-methylguanine from DNA.N-甲基-N-亚硝基脲的致癌性：DNA中O6-甲基鸟嘌呤切除修复的可能作用。

J Natl Cancer Inst. 1974 Dec;53(6):1839-41.

Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.单次经胎盘给予N-甲基-N-亚硝基脲后，各种大鼠胎儿和母体组织DNA中甲基化嘌呤的持续性及子代中的致癌作用。

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Repair of O6-methyl-guanine residues in DNA takes place by a similar mechanism in extracts from HeLa cells, human liver, and rat liver.在来自HeLa细胞、人肝脏和大鼠肝脏的提取物中，DNA中O6-甲基鸟嘌呤残基的修复通过类似的机制进行。

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Alkylation of DNA in rat tissues following administration of streptozotocin.链脲佐菌素给药后大鼠组织中DNA的烷基化作用。

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Site-specific mutagenesis induced by single O6-alkylguanines (O6-n-propyl, O6-n-butyl, O6-n-octyl) in vivo.体内由单个O6-烷基鸟嘌呤（O6-正丙基、O6-正丁基、O6-正辛基）诱导的位点特异性诱变。

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A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.小鼠肝脏中用于修复甲基化DNA中O6-甲基鸟嘌呤损伤的系统。

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