甲基鸟嘌呤-DNA甲基转移酶：个人观点。
MGMT: a personal perspective.
作者信息
Mitra Sankar
机构信息
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
出版信息
DNA Repair (Amst). 2007 Aug 1;6(8):1064-70. doi: 10.1016/j.dnarep.2007.03.007. Epub 2007 May 7.
Abstract
This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
摘要
本综述描述了关于哺乳动物基因组烷基化损伤及其致癌后果的研究历史，这些研究促成了一种名为MGMT的独特DNA修复蛋白的发现。MGMT可修复O(6)-烷基鸟嘌呤，这是一种由烷基化剂诱导产生的关键诱变损伤。本文总结了在大肠杆菌中发现这种普遍存在的修复蛋白后，在哺乳动物细胞中开展的后续研究。
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