甲基鸟嘌呤-DNA甲基转移酶：个人观点。
MGMT: a personal perspective.
作者信息
Mitra Sankar
机构信息
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
出版信息
DNA Repair (Amst). 2007 Aug 1;6(8):1064-70. doi: 10.1016/j.dnarep.2007.03.007. Epub 2007 May 7.
Abstract
This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
摘要
本综述描述了关于哺乳动物基因组烷基化损伤及其致癌后果的研究历史，这些研究促成了一种名为MGMT的独特DNA修复蛋白的发现。MGMT可修复O(6)-烷基鸟嘌呤，这是一种由烷基化剂诱导产生的关键诱变损伤。本文总结了在大肠杆菌中发现这种普遍存在的修复蛋白后，在哺乳动物细胞中开展的后续研究。
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本文引用的文献
1
Repair of alkylated DNA: recent advances.烷基化DNA的修复：最新进展
DNA Repair (Amst). 2007 Apr 1;6(4):429-42. doi: 10.1016/j.dnarep.2006.10.005. Epub 2006 Nov 16.
2
DNA damage-induced cell death by apoptosis.DNA损伤诱导细胞通过凋亡而死亡。
Trends Mol Med. 2006 Sep;12(9):440-50. doi: 10.1016/j.molmed.2006.07.007. Epub 2006 Aug 8.
3
The reaction of mustard gas with nucleic acids in vitro and in vivo.芥子气在体外和体内与核酸的反应。
Biochem J. 1960 Dec;77(3):478-84. doi: 10.1042/bj0770478.
4
The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein.大肠杆菌对烷化剂适应性反应中的AidB组分是一种含黄素的DNA结合蛋白。
J Bacteriol. 2006 Jan;188(1):223-30. doi: 10.1128/JB.188.1.223-230.2006.
5
Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.对单一类型DNA损伤——O(6)-甲基鸟嘌呤的凋亡信号传导。
Mol Cell. 2004 Apr 9;14(1):105-16. doi: 10.1016/s1097-2765(04)00162-5.
6
Dual repair modulation reverses Temozolomide resistance in vitro.双重修复调节在体外逆转替莫唑胺耐药性。
Mol Cancer Ther. 2004 Feb;3(2):123-7.
7
CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration.人O6-甲基鸟嘌呤-DNA甲基转移酶基因的CpG甲基化依赖性抑制与染色质结构改变有关。
Carcinogenesis. 2003 Aug;24(8):1337-45. doi: 10.1093/carcin/bgg086. Epub 2003 May 22.
8
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.人类和细菌的氧化脱甲基酶可修复RNA和DNA中的烷基化损伤。
Nature. 2003 Feb 20;421(6925):859-63. doi: 10.1038/nature01363.
9
The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin.O6-烷基鸟嘌呤-DNA烷基转移酶和错配修复活性对人黑色素瘤细胞对替莫唑胺、1,3-双(2-氯乙基)-1-亚硝基脲和顺铂敏感性的影响。
J Pharmacol Exp Ther. 2003 Feb;304(2):661-8. doi: 10.1124/jpet.102.043950.
10
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage.大肠杆菌AlkB介导的氧化脱甲基作用可直接修复DNA碱基损伤。
Nature. 2002 Sep 12;419(6903):174-8. doi: 10.1038/nature00908.
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