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[女性库欣综合征中的促性腺功能(作者译)]

[Gonadotropic function in female Cushing's syndrome (author's transl)].

作者信息

Thieblot P, Luton J P, Mahoudeau J, Bricaire H

出版信息

Ann Endocrinol (Paris). 1979 Jan-Feb;40(1):3-14.

PMID:443729
Abstract

Gonadotropic function has been studied without selection in 38 female patients with Cushing's syndrome followed during four years. The level of gonadotropins FSH and LH was low in all etiologies of the syndrome. LH-RH stimulation is normal in adrenal hyperplasia and adenoma, and very low in carcinoma. These abnormalities are cured after reduction of hypercorticism. The share of either cortisol or androgens is discussed. A predominant hypercortisolism blunting action on gonadotropic function is possible, cortisol being the common factor of Cushing's syndrome.

摘要

对38例库欣综合征女性患者进行了为期四年的无选择的促性腺功能研究。该综合征所有病因中促性腺激素FSH和LH水平均较低。在肾上腺增生和腺瘤中,LH-RH刺激正常,而在癌中则非常低。高皮质醇血症减轻后,这些异常情况可得到治愈。文中讨论了皮质醇或雄激素的作用占比。皮质醇作为库欣综合征的共同因素,可能对促性腺功能起主要的高皮质醇血症抑制作用。

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