Thieblot P, Luton J P, Mahoudeau J, Simon D, Bricaire H
Ann Endocrinol (Paris). 1979 Jul-Aug;40(4):429-30.
A study of 38 female Cushing syndromes showed decreased levels of FSH and LH, with normal LH-RH stimulation in most adrenal hyperplasia and benign adenoma, and absent stimulation in carcinoma. The levels were normalized by suppression of hypercorticism. This suggests a blunted gonadotropic function, in female Cushing syndrome, probably at the hypothalamic level. The predominant respective roles of hyperandrogeny in carcinoma and of hypercortisolism in adrenal hyperplasia and benign adenoma seem probable.
一项对38例女性库欣综合征的研究显示,促卵泡生成素(FSH)和促黄体生成素(LH)水平降低,在大多数肾上腺增生和良性腺瘤中,促黄体生成素释放激素(LH-RH)刺激试验结果正常,而在癌中则无刺激反应。通过抑制皮质醇增多症,这些水平恢复正常。这表明在女性库欣综合征中,促性腺功能可能在下丘脑水平受到抑制。雄激素过多在癌中的主要作用以及皮质醇增多症在肾上腺增生和良性腺瘤中的主要作用似乎是可能的。