Dubois P M, Alizon E, David L
Ann Endocrinol (Paris). 1979 Jan-Feb;40(1):53-4.
Calcitonin (CT)-cells were detected, by using an anti-human calcitonin serum (hCT), in the thyroid of the normal and anencephalic human fetuses. The first CT-cells were observed at 14 weeks of gestation. The CT-cells were at first isolated afterwards were appeared in parafollicular localization. The CT-cells were only observed in the middle of the upper or medium third or the lateral lobes, along the central axis of the lobes. No CT-cells were detected in the isthmic region or in the inferior third of the lobes. CT-cells were also seen in the thyroid of the anencephalic fetuses. The specificity of the immunocytological reaction was ascertained after incubation of anti-hCT serum with homologous or heterologous antigens: after incubation of the anti-hCT serum with hCT, the immunocytological reaction was disappeared, but no modification of the reaction was noted after incubation with somatostatin, T4 or parathormone. The CT appeared precociously in the thyroid of the human fetus and their localization was the same that in the older subjects.
使用抗人降钙素血清（hCT）在正常和无脑儿胎儿的甲状腺中检测到了降钙素（CT）细胞。在妊娠14周时观察到第一批CT细胞。CT细胞最初是孤立的，之后出现在滤泡旁定位。CT细胞仅在叶的上三分之一或中三分之一的中部或叶的侧叶沿着叶的中轴线观察到。在峡部区域或叶的下三分之一未检测到CT细胞。在无脑儿胎儿的甲状腺中也可见到CT细胞。在用同源或异源抗原孵育抗hCT血清后确定了免疫细胞反应的特异性：抗hCT血清与hCT孵育后，免疫细胞反应消失，但与生长抑素、T4或甲状旁腺激素孵育后未观察到反应改变。CT在人类胎儿的甲状腺中早熟出现，其定位与年长个体相同。
