Abraham-Inpijn L
Arch Chir Neerl. 1979;31(1):9-15.
In a clinical trial thromboembolic prophylaxis with subcutaneous low-dose heparin was given to 20 patients admitted for surgery on the larynx. All patients (40 totally) had a malignancy. The study was not primarily directed on the antithrombotic effect, but on complication factors. In the control group pulmonary embolism was found four times, but not in the group of patients receiving heparin. No increase of blood loss in the heparin group appeared, although this group included very difficult operations. No complications were seen to arise from the injections of the heparin.
在一项临床试验中，对20名因喉部手术入院的患者给予皮下低剂量肝素进行血栓栓塞预防。所有患者（共40名）均患有恶性肿瘤。该研究主要不是针对抗血栓形成作用，而是针对并发症因素。在对照组中发现有4例发生肺栓塞，但在接受肝素治疗的患者组中未发现。尽管肝素组包括一些非常困难的手术，但该组并未出现失血增加的情况。未观察到肝素注射引发任何并发症。
