Suter L, Tilkorn H, Kövary P M
Arch Dermatol Res. 1979 Feb 23;264(1):37-47. doi: 10.1007/BF00417277.
Tumor-associated antigens were demonstrated in phenol water extracts of human malignant melanoma by migration tests with leukocytes from melanoma patients and controls: in 25 out of 60 melanoma patients weak reactivity was observed, usually stimulation of leukocyte migration, while leukocytes from 37 controls were negative in 100 tests. The frequency of positive reactions did not differ significantly in patients with and without metastases. Humoral antibodies against antigens of phenol water extracts were not detectable in melanoma patients. Rabbits did not produce antibodies against tumor typical substances after immunization with phenol water extracts. Tumor associated antigens of phenol water extracts are presumably not targets of antitumor immune reactions that can influence the clinical course.
通过对黑色素瘤患者和对照者的白细胞进行迁移试验，在人恶性黑色素瘤的酚水提取物中证实了肿瘤相关抗原：在60例黑色素瘤患者中，有25例观察到弱反应性，通常是白细胞迁移受到刺激，而在100次试验中，37名对照者的白细胞均为阴性。有转移和无转移的患者中阳性反应的频率没有显著差异。在黑色素瘤患者中未检测到针对酚水提取物抗原的体液抗体。用酚水提取物免疫后，兔子未产生针对肿瘤典型物质的抗体。酚水提取物的肿瘤相关抗原可能不是可影响临床病程的抗肿瘤免疫反应的靶点。
