Cloup M, Kaminski M, Brauner-Karray R, Goujard J, Cloup I, Chlabovitch E, Chassevent J, Lavaud J
Arch Fr Pediatr. 1979 Feb;36(2):207-16.
From 1964 to 1976, 854 children were admitted with poisoning to three intensive care units in Paris. The severity of the condition has been assessed in terms of the patients received: 1. observation only (67%). 2. routine intensive care (27%). 3. very seriously ill (6%). At the time of discharge, 92% of children were normal, 3% had minor sequelae, 3% had major sequelae; 2% died. The outcome was closely related to the severity of the illness. The main factors affecting the severity were: 1. The nature of the ingested substance. Poisoning with Amanita phalloides was the most serious with a high mortality. Poisoning with domestic agricultural and industrial products were more often responsible for major sequelae, particularly affecting the oesophagus, than drugs. 2. The type of poisoning. This was related to the age of the child. Iatrogenic poisoning of infants and self poisoning by adolescents were more serious than accidental poisoning in toddlers. 3. The toxicity of the ingested dose. 4. The interval between ingestion and effective treatment. Although all the factors are interrelated, each factor has its own prognostic value.
1964年至1976年期间，854名中毒儿童被收治于巴黎的三个重症监护病房。根据患儿接受的治疗情况对病情严重程度进行了评估：1. 仅接受观察（67%）。2. 接受常规重症监护（27%）。3. 病情非常严重（6%）。出院时，92%的儿童恢复正常，3%有轻微后遗症，3%有严重后遗症；2%死亡。预后与疾病严重程度密切相关。影响严重程度的主要因素有：1. 摄入物质的性质。毒蝇伞中毒最为严重，死亡率很高。与药物相比，家用农用和工业产品中毒更常导致严重后遗症，尤其是影响食管。2. 中毒类型。这与儿童年龄有关。婴儿的医源性中毒和青少年的自我中毒比幼儿的意外中毒更严重。3. 摄入剂量的毒性。4. 摄入与有效治疗之间的间隔。虽然所有因素相互关联，但每个因素都有其自身的预后价值。
