IME——一种从小鼠胚胎组织中分离出的干扰素活性抑制剂。II.生物学特性。
IME -- an inhibitor of interferon activity isolated from mouse embryonic tissues. II. Biological characteristics.
作者信息
Cembrzyńska-Nowak M
出版信息
Arch Immunol Ther Exp (Warsz). 1979;27(1-2):229-39.
The biological properties and mode of action of IME were studied. Extracts of homogenized and lyophilized mouse embryos served as source of IME, which was found to be localized mainly in cells of mouse amnionic membranes and embryonic tissues. Growth of embryos was accompanied by falling activity of the inhibitor. IME activity was manifested only if it acted on cells in established antiviral state, and only in systems with efficient protein synthesis in all stages. IME stimultes cell metabolism. The findings from this study constitute material for further research on factors antagonistic to interferon.
对免疫调制提取物（IME）的生物学特性和作用方式进行了研究。将匀浆并冻干的小鼠胚胎提取物用作IME的来源，发现其主要定位于小鼠羊膜和胚胎组织的细胞中。胚胎生长伴随着抑制剂活性的下降。IME活性只有在作用于处于已建立抗病毒状态的细胞时才会表现出来，并且仅在所有阶段都具有高效蛋白质合成的系统中才会表现出来。IME刺激细胞代谢。这项研究的结果为进一步研究干扰素拮抗因子提供了素材。
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