Rosztóczy I
Acta Virol. 1977 Jan;21(1):1-7.
Actinomycin D at a concentration inhibitory for nucleolar RNA synthesis did not influence the development of priming. Higher concentrations of the drug and long-term alpha-amanitin or cycloheximide pretreatments, inhibitory for heterogenous nuclear RNA synthesis, prevented the establishment of the primed state. The inhibition of mitochondrial DNA and protein synthesis did not inhibit the priming effect of interferon. Attempts to prime cells with pretreatments other than interferon were not successful.
放线菌素D在抑制核仁RNA合成的浓度下并不影响引发作用的发展。更高浓度的该药物以及长期的α-鹅膏蕈碱或环己酰亚胺预处理可抑制异质性核RNA合成，从而阻止引发状态的建立。线粒体DNA和蛋白质合成的抑制并未抑制干扰素的引发效应。用除干扰素之外的预处理对细胞进行引发的尝试未获成功。
