左旋咪唑对大鼠佐剂性多关节炎病程的调节作用。
Modifying action of levamisole on the course of adjuvant-induced polyarthritis in rats.
作者信息
Brajczewska-Fischer W, Szpilman H, Ryzèwska A
出版信息
Arch Immunol Ther Exp (Warsz). 1979;27(1-2):241-6.
Treatment of August rats with levamisole (L-tetramisole) distinctly depressed the development and the course of adjuvant-induced polarthritis (A-pa). The depressing activity of the drug was dose-dependent. However, spontaneous stimulation of lymphocytes from A-pa rats treated with levamisole was decreased only after the first 7 days of treatment. Moreover, these lymphocytes showed no changes in PHA-reactivity in comparison with untreated animals. It was concluded that levamisole in some circumstances may show immunosuppressive activity; however, it did not seem to act directly on lymphocytes.
用左旋咪唑（L-四咪唑）治疗奥古斯特大鼠，可明显抑制佐剂诱导的多关节炎（A-pa）的发展和病程。该药物的抑制活性呈剂量依赖性。然而，仅在治疗的前7天后，用左旋咪唑治疗的A-pa大鼠淋巴细胞的自发刺激才降低。此外，与未治疗的动物相比，这些淋巴细胞的PHA反应性没有变化。得出的结论是，左旋咪唑在某些情况下可能表现出免疫抑制活性；然而，它似乎并不直接作用于淋巴细胞。
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