Sibiriak S V, Lazereva D N, Kokhanchikova N A
Farmakol Toksikol. 1984 Nov-Dec;47(6):84-7.
Effects of levamisole and prodigizan on the development of adjuvant arthritis, the level of circulating immune complexes (CIC) and spontaneous stimulation of adjacent lymph nodes were studied on 150 noninbred rats. Administration of levamisole in a dose of 2.5 mg/kg bw daily from the first to the 12th day after injection of complete Freund's adjuvant inhibited the disease development. On the 7th day after induction the level of CIC was increased and in-vitro 3H-thymidine incorporation into adjacent lymph node cells was recorded as compared with untreated animals. Administration of prodigiozan in a dose of 0.5 mg/kg bw once in 4 days within the same period of time inhibited the development of arthritis, increased adjacent lymph node stimulation and had no influence on the level of CIC. The changes in the immunological characteristics in the inductive phase of the disease suggest that the effects of the drugs are mediated via macrophages.
在150只非近交系大鼠身上研究了左旋咪唑和丙嗪对佐剂性关节炎发展、循环免疫复合物（CIC）水平以及邻近淋巴结自发刺激的影响。从注射完全弗氏佐剂后的第1天至第12天，每日以2.5毫克/千克体重的剂量给予左旋咪唑，可抑制疾病发展。诱导后第7天，与未治疗的动物相比，CIC水平升高，且记录到邻近淋巴结细胞的体外3H-胸腺嘧啶核苷掺入增加。在同一时间段内，每4天以0.5毫克/千克体重的剂量给予丙嗪一次，可抑制关节炎发展，增加邻近淋巴结刺激，且对CIC水平无影响。疾病诱导期免疫特性的变化表明，药物的作用是通过巨噬细胞介导的。
