Kogoĭ T F
Arkh Patol. 1979;41(4):62-4.
The paper describes two cases of congenital rubeolar embryo- and fetopathy which show that in infection with rubella virus in the 1st trimester of pregnancy the virus effect may be limited to the period of embryogenesis or extend to the fetal period as well. In the first instance, multiple developmental defects occur at the organ level; in prolonged virus effect organogenesis disorders are combined with tissue displasias and inflammatory processes, that is, the pathology typical of the fetal period. Congenital rubella is characterized by a subacute course and wide generalization of the alterative-productive inflammation: productive dermatitis, subacute productive-necrotic encephalitis and endophthalmitis, as well as giant-cell metamorphosis of alveolocytes.
本文描述了两例先天性风疹胚胎病和胎儿病病例，这些病例表明，在妊娠早期感染风疹病毒时，病毒的影响可能仅限于胚胎发生期，也可能延伸至胎儿期。在第一种情况下，器官水平会出现多种发育缺陷；在病毒长期影响下，器官发生障碍会与组织发育异常和炎症过程相结合，即胎儿期典型的病理变化。先天性风疹的特点是亚急性病程和交替性增殖性炎症的广泛扩散：增殖性皮炎、亚急性增殖性坏死性脑炎和眼内炎，以及肺泡细胞的巨细胞变形。
