Rapoport I, Elsner R, Müller M, Dumdey R, Rapoport S
Acta Biol Med Ger. 1979;38(7):901-8.
Studies have been carried out on human erythrocytes in vitro to clarify the deficit of pyruvate formation under conditions when 2,3 DPG is degraded. The results lead to the conclusion that there exist a cross connection between the glycolytic and the oxidative pentose phosphate pathway which is mediated by the NADP/NADPH couple. NADPH serves as additional reducing equivalent in the reaction of the LDH. In the absence of glucose the pool of the metabolites of the pentose phosphate pathway is able to supply glucose-6-phosphate for the production of NADPH by recombination. The reaction of NADPH at the LDH is probably of significance under in vivo conditions.
已经在体外对人体红细胞进行了研究，以阐明在2,3-二磷酸甘油酸（2,3 DPG）降解的条件下丙酮酸生成的不足。结果得出结论，糖酵解途径和氧化戊糖磷酸途径之间存在由NADP/NADPH偶联介导的交叉联系。NADPH在乳酸脱氢酶（LDH）反应中作为额外的还原当量。在没有葡萄糖的情况下，戊糖磷酸途径的代谢产物池能够通过重组提供葡萄糖-6-磷酸用于NADPH的生成。NADPH在LDH处的反应在体内条件下可能具有重要意义。
