Ataullakhanov F I, Buravtsev V N, Zhabotinskiĩ A M, Norina S B, Pichugin A V
Biokhimiia. 1981 Apr;46(4):723-31.
A mathematical model of glycolysis in human erythrocytes for the interaction between the Embden-Meyerhof and the pentose phosphate pathways has been developed. The characteristic surfaces, i. e. interdependencies between the rates of metabolite flows in both pathways and ATP and NADPH concentrations have been calculated. The model obtained is well correlated with the experimental data on glycolysis characteristic at low rates of the pentose phosphate pathway reactions. The model suggests that NADPH and GSH concentrations should be stabilized. At ATP and NADPH concentrations close to the physiological ones the Embden-Meyerhof and pentose phosphate pathways function practically independently. When the NADPH concentration is decreased below 80% of the physiological value, the system ceases to stabilize the ATP concentration. In its turn, a decrease of ATP concentration results in a corresponding decrease of the maximal rate of the pentose phosphate pathway.
已建立了一个关于人类红细胞糖酵解的数学模型，用于描述糖酵解途径（Embden-Meyerhof途径）和磷酸戊糖途径之间的相互作用。计算了特征表面，即两条途径中代谢物流速与ATP和NADPH浓度之间的相互依存关系。所得到的模型与磷酸戊糖途径反应低速率下糖酵解特征的实验数据具有良好的相关性。该模型表明NADPH和谷胱甘肽（GSH）浓度应保持稳定。当ATP和NADPH浓度接近生理浓度时，糖酵解途径和磷酸戊糖途径实际上是独立发挥作用的。当NADPH浓度降至生理值的80%以下时，该系统便不再能稳定ATP浓度。反过来，ATP浓度的降低会导致磷酸戊糖途径最大速率相应下降。
