Kaplan M, Register D C, Bierman A H, Risacher R L
Clin Toxicol. 1974;7(5):509-12. doi: 10.3109/15563657408988023.
Scopolamine, a drug not usually found in poisoning, was found to be the cause of toxicity in three persons. This paper stresses the need to confirm any unusual iodoplatinate spots that may occur in emergency drug screening. Gastric lavages appear to be the most useful source for recovering belladonna compounds as no scopolamine was found in the urine, either at admission or the day after. Atropine and scopolamine are easily separated from each other by TLC and GLC but homatropine separates poorly from atropine.
东莨菪碱是一种在中毒情况中通常不会出现的药物,却被发现是三名患者中毒的原因。本文强调了在紧急药物筛查中确认任何可能出现的异常碘铂酸盐斑点的必要性。洗胃似乎是回收颠茄化合物最有用的来源,因为在入院时或之后一天的尿液中均未发现东莨菪碱。阿托品和东莨菪碱很容易通过薄层色谱法(TLC)和气相色谱法(GLC)彼此分离,但后马托品与阿托品的分离效果较差。