肝胆疾病中的血浆碱性磷酸酶同工酶
Plasma alkaline phosphatase isoenzymes in hepatobiliary disease.
作者信息
Afonija A O, Baron D N
出版信息
J Clin Pathol. 1974 Nov;27(11):916-20. doi: 10.1136/jcp.27.11.916.
Abstract
BY CELLULOSE ACETATE OR ACRYLAMIDE GEL ELECTROPHORESIS IT IS POSSIBLE TO SEPARATE THESE ALKALINE PHOSPHATASE ISOENZYMES FROM SERUM
[anode] fast liver, slow liver, placenta/Regan, bone, intestine, bile [cathode]. Heat or chemical inhibition can confirm the differentiation. Normal adult serum always contains slow-liver isoenzyme, and sometimes bone isoenzyme: the latter is always present in serum of children. In hepatobiliary disease slow-liver isoenzyme was always increased: intestinal isoenzyme appeared in many cases of cirrhosis (of blood groups B and 0) but fast-liver and bile isoenzymes were occasionally seen in miscellaneous cases. The findings in other diseases included Regan isoenzyme in six out of 45 cases of malignant disease.
摘要
通过醋酸纤维素或丙烯酰胺凝胶电泳可以从血清中分离出这些碱性磷酸酶同工酶
[阳极] 快速肝型、慢速肝型、胎盘/雷根型、骨型、肠型、胆汁型 [阴极]。加热或化学抑制可证实这种区分。正常成人血清始终含有慢速肝型同工酶，有时还含有骨型同工酶：后者在儿童血清中始终存在。在肝胆疾病中，慢速肝型同工酶总是升高：肠型同工酶在许多肝硬化病例（B 型和 O 型血）中出现，但快速肝型和胆汁型同工酶偶尔在其他杂症病例中可见。其他疾病的研究结果包括在 45 例恶性疾病中有 6 例出现雷根型同工酶。
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