• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Lipid solubility and drug penetration of the blood brain barrier.

作者信息

Oldendorf W H

出版信息

Proc Soc Exp Biol Med. 1974 Dec;147(3):813-5. doi: 10.3181/00379727-147-38444.

DOI:10.3181/00379727-147-38444
PMID:4445171
Abstract
摘要

相似文献

1
Lipid solubility and drug penetration of the blood brain barrier.脂溶性与药物对血脑屏障的穿透性。
Proc Soc Exp Biol Med. 1974 Dec;147(3):813-5. doi: 10.3181/00379727-147-38444.
2
Maternal and fetal distribution of drugs in pregnancy.
Clin Pharmacol Ther. 1973 Jul-Aug;14(4):643-7. doi: 10.1002/cpt1973144part2643.
3
[Blood-brain barrier and the penetration of cytostatic drugs].[血脑屏障与细胞毒性药物的渗透]
Klin Wochenschr. 1985 Jun 18;63(12):565-71. doi: 10.1007/BF01733202.
4
Localization in brain particulate fractions of narcotic analgesic drugs administered intracisternally to rats.
Biochem Pharmacol. 1973 Jun 1;22(11):1283-93. doi: 10.1016/0006-2952(73)90302-x.
5
Penetration of some O-and/or N-methylated norepinephrine derivatives through the rat blood brain barrier.
Res Commun Chem Pathol Pharmacol. 1977 May;17(1):61-76.
6
Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.开发一种人源化体外血脑屏障模型以筛选抗癫痫药物的脑渗透性。
Epilepsia. 2007 Mar;48(3):505-16. doi: 10.1111/j.1528-1167.2006.00960.x. Epub 2007 Feb 22.
7
[Effect of a single ethanol administration on the permeability of the hemato-encephalic barrier for 14C-tyrosine, 14C-DOPA and horseradish peroxidase].[单次给予乙醇对血脑屏障对14C-酪氨酸、14C-多巴和辣根过氧化物酶通透性的影响]
Biull Eksp Biol Med. 1986 Mar;101(3):331-4.
8
Blood-brain barrier permeability to bilirubin in the rat studied using intracarotid bolus injection and in situ brain perfusion techniques.
Pediatr Res. 1990 May;27(5):436-41. doi: 10.1203/00006450-199005000-00004.
9
Proceedings: Studies on the interference of 14C-pentobarbital, 14C-diphenylhydantoin and 3H-digitoxin with ethanol in the isolated perfused guinea-pig liver.
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R49.
10
Studies of the development of brain barrier systems to lipid insoluble molecules in fetal sheep.胎儿绵羊中脑屏障系统对脂溶性分子发育的研究。
J Physiol. 1979 Jul;292:207-31. doi: 10.1113/jphysiol.1979.sp012847.

引用本文的文献

1
Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique.使用原位脑灌注技术在10个数量级上评估脑内皮通透性、转运和血流。
Fluids Barriers CNS. 2024 Dec 17;21(1):100. doi: 10.1186/s12987-024-00584-y.
2
The penetration of therapeutics across the blood-brain barrier: Classic case studies and clinical implications.治疗药物穿越血脑屏障的渗透：经典案例研究及其临床意义。
Cell Rep Med. 2024 Nov 19;5(11):101760. doi: 10.1016/j.xcrm.2024.101760. Epub 2024 Oct 8.
3
: A Comprehensive Study on Laboratory Cultivation and Anticancer Potential in Dalton's Ascites Lymphoma Tumor Model.
: 关于在道尔顿腹水淋巴瘤肿瘤模型中进行实验室培养和抗癌潜力的综合研究。
Anticancer Agents Med Chem. 2024;24(9):668-690. doi: 10.2174/0118715206282174240115082518.
4
Neuroprotective Properties of Oleanolic Acid-Computational-Driven Molecular Research Combined with In Vitro and In Vivo Experiments.齐墩果酸的神经保护特性——计算驱动的分子研究与体外和体内实验相结合
Pharmaceuticals (Basel). 2023 Aug 31;16(9):1234. doi: 10.3390/ph16091234.
5
Anti-Hormonal Therapy in Breast Cancer and Its Effect on the Blood-Brain Barrier.乳腺癌的抗激素治疗及其对血脑屏障的影响。
Cancers (Basel). 2022 Oct 19;14(20):5132. doi: 10.3390/cancers14205132.
6
A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats.低白蛋白水平作为钆塞酸二钠给药诱发短暂严重运动伪影的危险因素：一项采用自由呼吸动态MRI的回顾性观察研究及大鼠实验研究
PLoS One. 2022 Mar 18;17(3):e0265588. doi: 10.1371/journal.pone.0265588. eCollection 2022.
7
Opioids and pituitary function: expert opinion.阿片类药物与垂体功能：专家意见。
Pituitary. 2022 Feb;25(1):52-63. doi: 10.1007/s11102-021-01202-y. Epub 2022 Jan 23.
8
An Effective and Safe Enkephalin Analog for Antinociception.一种有效且安全的用于抗伤害感受的脑啡肽类似物。
Pharmaceutics. 2021 Jun 22;13(7):927. doi: 10.3390/pharmaceutics13070927.
9
Investigation of the Structure-Activity Relationships of Psilocybin Analogues.裸盖菇素类似物的构效关系研究
ACS Pharmacol Transl Sci. 2020 Dec 14;4(2):533-542. doi: 10.1021/acsptsci.0c00176. eCollection 2021 Apr 9.
10
Advances in the Physicochemical Profiling of Opioid Compounds of Therapeutic Interest.具有治疗意义的阿片类化合物的物理化学分析进展
ChemistryOpen. 2019 Jul 4;8(7):879-887. doi: 10.1002/open.201900115. eCollection 2019 Jul.