Manninen A, Kröger S, Liesivuori J, Savolainen H
Kuopio Regional Institute of Occupational Health, Finland.
Arch Toxicol. 1989;63(2):160-1. doi: 10.1007/BF00316441.
Adult male 3-month-old Wistar rats were given 0, 100 mg/l, 1, 5 or 10 g/l 2-ethylhexanoic acid in their drinking water for 20 days. Their daily consumption of contaminated water was measured and compared with the free acid found in their 24-h urine samples. The excretion was dose and time dependent. At the termination of the experiment, liver mitochondrial carnitine acetyltransferase activity was induced dose dependently and the citrulline synthesis in the urea cycle inhibited. Our results compare very well with the toxicity of a structural congener of the 2-ethylhexanoic acid, i.e. valproate, an antiepileptic drug.
将成年雄性3月龄Wistar大鼠的饮用水中分别加入0、100毫克/升、1、5或10克/升的2-乙基己酸，持续20天。测量它们每日对受污染水的消耗量，并与24小时尿液样本中发现的游离酸进行比较。排泄量呈剂量和时间依赖性。实验结束时，肝脏线粒体肉碱乙酰转移酶活性呈剂量依赖性诱导，尿素循环中的瓜氨酸合成受到抑制。我们的结果与2-乙基己酸的结构类似物丙戊酸盐（一种抗癫痫药物）的毒性非常吻合。
