DL-、D-和L-普萘洛尔与人红细胞葡萄糖转运系统的相互作用。
Interaction of DL-, D- and L-propranolol with the transport system of glucose in human erythrocytes.
作者信息
Lacko L, Wittke B, Lacko I
出版信息
Arzneimittelforschung. 1979;29(11):1685-7.
PMID:44472
Abstract
The effect of D-, L- and DL-propranolol on the glucose uptake in human erythrocytes was studied. It was observed that all three compounds competitively inhibit the glucose transport and have identical inhibition constants. The pH dependence of the inhibition constant indicates that uncharged propranolol is a more potent inhibitor than the charged one. The thermodynamic parameters of the interaction of propranolol with the glucose transport system were determined and discussed.
摘要
研究了D-、L-和DL-普萘洛尔对人红细胞葡萄糖摄取的影响。观察到所有这三种化合物均竞争性抑制葡萄糖转运，且具有相同的抑制常数。抑制常数对pH的依赖性表明，不带电荷的普萘洛尔比带电荷的普萘洛尔是更有效的抑制剂。测定并讨论了普萘洛尔与葡萄糖转运系统相互作用的热力学参数。
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