大鼠体内酚酸的代谢
The metabolism of phenolic acids in the rat.
作者信息
Ranganathan S, Ramasarma T
出版信息
Biochem J. 1974 Jun;140(3):517-22. doi: 10.1042/bj1400517.
Some of the enzyme systems in the formation of p-hydroxybenzoate from tyrosine have been studied in the rat liver in vitro. The conversion of p-hydroxycinnamate into p-hydroxybenzoate, which was found in rat liver mitochondria showed a number of differences when compared with the beta-oxidation of fatty acids. Studies with p-hydroxy[U-(14)C]cinnamate indicated that (14)CO(2) was released during the formation of p-hydroxybenzoate. The formation of p-hydroxycinnamate from tyrosine of p-hydroxyphenyl-lactate could not be demonstrated in vitro. The interconversion of p-hydroxycinnamate and p-hydroxyphenylpropionate was demonstrated in rat liver mitochondria.
已在体外对大鼠肝脏中由酪氨酸形成对羟基苯甲酸酯的一些酶系统进行了研究。在大鼠肝脏线粒体中发现的对羟基肉桂酸酯转化为对羟基苯甲酸酯的过程，与脂肪酸的β氧化相比存在一些差异。用对羟基[U-(14)C]肉桂酸酯进行的研究表明，在对羟基苯甲酸酯形成过程中会释放出(14)CO(2)。在体外无法证明由酪氨酸或对羟基苯乳酸形成对羟基肉桂酸酯。在大鼠肝脏线粒体中证明了对羟基肉桂酸酯和对羟基苯丙酸酯之间的相互转化。
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