α-氰基-4-羟基肉桂酸对大鼠肝脏线粒体和人红细胞中丙酮酸转运的特异性抑制作用。
Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate.
作者信息
Halestrap A P, Denton R M
出版信息
Biochem J. 1974 Feb;138(2):313-6. doi: 10.1042/bj1380313.
Abstract
alpha-Cyano-4-hydroxycinnamate greatly inhibits the transport of pyruvate but not that of acetate or butyrate in liver mitochondria and erythrocytes. In the latter, lactate uptake is also inhibited. It is concluded that a specific carrier is involved in membrane transport of pyruvate and that the plasma-membrane carrier may also be involved in lactate transport.
摘要
α-氰基-4-羟基肉桂酸能显著抑制肝脏线粒体和红细胞中丙酮酸的转运，但不影响乙酸或丁酸的转运。在红细胞中，乳酸摄取也受到抑制。由此得出结论，丙酮酸的膜转运涉及一种特异性载体，并且质膜载体可能也参与乳酸的转运。
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