用无线电遥测装置测量乳果糖和其他泻药对回肠和结肠pH值的影响。
Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device.
作者信息
Bown R L, Gibson J A, Sladen G E, Hicks B, Dawson A M
出版信息
Gut. 1974 Dec;15(12):999-1004. doi: 10.1136/gut.15.12.999.
Abstract
Using a pH-sensitive radiotelemetering device the effect of lactulose on luminal pH in the ileum, colon, and rectum has been compared with that of two other laxative agents. Lactulose produced marked acidification of proximal colonic contents but this effect was not consistently maintained into the distal colon. Sodium sulphate acidified distal rather than proximal colonic contents. However, for a similar degree of laxation it was not possible to produce a significantly more uniform reduction of pH along the length of the colon by combining these laxatives compared with lactulose alone. Magnesium sulphate had little effect upon luminal pH except in the rectum where a significant rise occurred. These results are discussed in relation to both normal colonic physiology and to their possible relevance to the treatment of chronic hepatic encephalopathy by colonic acidification.
摘要
使用一种对pH敏感的无线电遥测装置，已将乳果糖对回肠、结肠和直肠腔内pH的影响与另外两种泻药的影响进行了比较。乳果糖使近端结肠内容物显著酸化，但这种作用在远端结肠并未持续维持。硫酸钠使远端而非近端结肠内容物酸化。然而，对于相似程度的通便作用，与单独使用乳果糖相比，联合使用这些泻药并不能使结肠全长的pH更均匀地显著降低。硫酸镁对腔内pH几乎没有影响，除了在直肠中出现显著升高。结合正常结肠生理学以及它们与通过结肠酸化治疗慢性肝性脑病的可能相关性对这些结果进行了讨论。
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