用无线电遥测装置测量乳果糖和其他泻药对回肠和结肠pH值的影响。
Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device.
作者信息
Bown R L, Gibson J A, Sladen G E, Hicks B, Dawson A M
出版信息
Gut. 1974 Dec;15(12):999-1004. doi: 10.1136/gut.15.12.999.
Abstract
Using a pH-sensitive radiotelemetering device the effect of lactulose on luminal pH in the ileum, colon, and rectum has been compared with that of two other laxative agents. Lactulose produced marked acidification of proximal colonic contents but this effect was not consistently maintained into the distal colon. Sodium sulphate acidified distal rather than proximal colonic contents. However, for a similar degree of laxation it was not possible to produce a significantly more uniform reduction of pH along the length of the colon by combining these laxatives compared with lactulose alone. Magnesium sulphate had little effect upon luminal pH except in the rectum where a significant rise occurred. These results are discussed in relation to both normal colonic physiology and to their possible relevance to the treatment of chronic hepatic encephalopathy by colonic acidification.
摘要
使用一种对pH敏感的无线电遥测装置，已将乳果糖对回肠、结肠和直肠腔内pH的影响与另外两种泻药的影响进行了比较。乳果糖使近端结肠内容物显著酸化，但这种作用在远端结肠并未持续维持。硫酸钠使远端而非近端结肠内容物酸化。然而，对于相似程度的通便作用，与单独使用乳果糖相比，联合使用这些泻药并不能使结肠全长的pH更均匀地显著降低。硫酸镁对腔内pH几乎没有影响，除了在直肠中出现显著升高。结合正常结肠生理学以及它们与通过结肠酸化治疗慢性肝性脑病的可能相关性对这些结果进行了讨论。
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本文引用的文献
1
LACTASE DEFICIENCY IN ADULTS. A CAUSE OF "FUNCTIONAL" DIARRHOEA.成人乳糖酶缺乏症：“功能性”腹泻的一个病因
Lancet. 1965 Apr 3;1(7388):717-20. doi: 10.1016/s0140-6736(65)92081-7.
2
ACQUIRED MILK INTOLERANCE IN THE ADULT CAUSED BY LACTOSE MALABSORPTION DUE TO A SELECTIVE DEFICIENCY OF INTESTINAL LACTASE ACTIVITY.由于肠道乳糖酶活性选择性缺乏导致乳糖吸收不良引起的成人获得性乳糖不耐受。
Am J Med. 1965 Jan;38:7-30. doi: 10.1016/0002-9343(65)90156-7.
3
ABSORPTION OF SHORT CHAIN FATTY ACIDS IN MAN.人体对短链脂肪酸的吸收
Proc Soc Exp Biol Med. 1964 Oct;117:97-100. doi: 10.3181/00379727-117-29505.
4
[STUDIES ON THE MECHANISM OF ACTION OF LACTULOSE (BETA-GALACTOSIDE ACTION OF LACTULOSE (BETA-GALACTOSIDO-FRUCTOSE) IN THE INTESTINE].乳果糖（β-半乳糖苷果糖）在肠道中的作用机制研究（乳果糖的β-半乳糖苷作用）
Klin Wochenschr. 1964 Feb 1;42:126-30. doi: 10.1007/BF01479054.
5
Absorption of lactic acid from an isolated intestinal segment in the intact rat.乳酸从完整大鼠的离体肠段的吸收。
Proc Soc Exp Biol Med. 1968 Apr;127(4):1103-6. doi: 10.3181/00379727-127-32882.
6
Lactulose treatment of hepatic encephalopathy in outpatients.
Arch Surg. 1971 Jan;102(1):25-7. doi: 10.1001/archsurg.1971.01350010027006.
7
Assessment and significance of bacterial overgrowth in the small bowel.小肠细菌过度生长的评估及其意义
Q J Med. 1970 Apr;39(154):265-85.
8
Some observations on the effects of treatment with lactulose on patients with chronic hepatic encephalopathy.关于乳果糖治疗慢性肝性脑病患者效果的一些观察
Q J Med. 1970 Apr;39(154):245-63.
9
Treatment of chronic portal-systemic encephalopathy with lactulose. Report of six patients and review of the literature.
Am J Med. 1971 Aug;51(2):148-59. doi: 10.1016/0002-9343(71)90233-6.
10
Electrolyte absorption and secretion in the human colon.人体结肠中的电解质吸收与分泌
Am J Dig Dis. 1972 Nov;17(11):1003-11. doi: 10.1007/BF02239140.
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