Gale R P
Haematol Blood Transfus. 1979;23:71-8. doi: 10.1007/978-3-642-67057-2_8.
Bone marrow transplantation is an experimental approach to the treatment of patients with acute leukemia, aplastic anemia, and other neoplastic and genetic diseases. To date, long-term disease-free survival has been achieved in a small proportion of carefully selected patients with resistant acute leukemia. While results are not optimal, they are acceptable in late stage patients where there are no effective alterates. Major problems in marrow transplantation for leukemia include tumor resistance and a spectrum of immunologic complications including GVHD, immunodeficiency, and interstitial pneumonitis. Potential approaches to these problems have been suggested. Progress in any one area would have a substantial impact on improving survival and extending the applicability of marrow transplantation to patients at an earlier stage of their disease.
骨髓移植是一种治疗急性白血病、再生障碍性贫血以及其他肿瘤性和遗传性疾病患者的实验性方法。迄今为止，在一小部分经过精心挑选的耐药急性白血病患者中实现了长期无病生存。虽然结果并非最佳，但对于没有有效替代疗法的晚期患者来说是可以接受的。白血病骨髓移植的主要问题包括肿瘤耐药性以及一系列免疫并发症，如移植物抗宿主病、免疫缺陷和间质性肺炎。针对这些问题已经提出了一些潜在的解决方法。任何一个领域的进展都将对提高生存率以及将骨髓移植的适用性扩展到疾病早期患者产生重大影响。
