庆大霉素和卡那霉素在血液透析期间的药代动力学。
Pharmacokinetics of gentamicin and kanamycin during hemodialysis.
作者信息
Danish M, Schultz R, Jusko W J
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):841-7. doi: 10.1128/AAC.6.6.841.
Abstract
The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and creatinine. The pharmacokinetic data were used to make dosage regimen recommendations for treatment of hemodialysis patients with these antibiotics.
摘要
在接受血液透析的患者中研究了庆大霉素、卡那霉素和肌酐的药代动力学。静脉注射单剂量药物后，在6小时内两种抗生素剂量的50%至60%从体内清除；这几乎完全是通过血液透析过程实现的。未发现氨基糖苷类药物的透析率与肌酐之间存在相关性。药代动力学数据用于为使用这些抗生素治疗血液透析患者制定给药方案建议。
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