头孢唑林的体外研究。
In vitro studies with cefazolin.
作者信息
Motley M, Shadomy S
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):856-61. doi: 10.1128/AAC.6.6.856.
Susceptibilities of 259 isolates of pathogenic bacteria to cefazolin were measured by broth and agar dilution procedures. Beta-hemolytic streptococci were inhibited by 0.25 mug/ml, whereas Staphylococcus aureus and alphahemolytic streptococci were inhibited by 2.0 mug/ml. Enterococci were resistant to less than 32 mug/ml. Wide variation was seen with gram-negative species. Most isolates of Klebsiella species and Proteus mirabilis were inhibited by 4.0 or 8.0 mug/ml. Escherichia coli were less susceptible, and most isolates of Pseudomonas aeruginosa, Serratia species, and Enterobacter species were resistant to 128 mug/ml.
采用肉汤稀释法和琼脂稀释法测定了259株病原菌对头孢唑林的敏感性。β-溶血性链球菌对头孢唑林的最低抑菌浓度为0.25μg/ml，金黄色葡萄球菌和α-溶血性链球菌为2.0μg/ml。肠球菌对头孢唑林的耐药浓度低于32μg/ml。革兰阴性菌的敏感性差异较大。大多数肺炎克雷伯菌和奇异变形杆菌菌株对头孢唑林的最低抑菌浓度为4.0或8.0μg/ml。大肠埃希菌的敏感性较低，大多数铜绿假单胞菌、沙雷菌属和肠杆菌属菌株对头孢唑林耐药，耐药浓度达128μg/ml。
Zotero 插件