大鼠中，3-己氨甲酰胆碱对脑室内注射新斯的明所致升压反应的抑制作用的品系差异。
Strain differences in the inhibition by hemicholinium-3 of the pressor response to intraventricular injection of neostigmine in rats.
作者信息
Brezenoff H E, Rusin J
出版信息
Br J Pharmacol. 1974 Jun;51(2):301-3. doi: 10.1111/j.1476-5381.1974.tb09660.x.
The pressor response to intracerebroventricular (i.c.v.) injections of neostigmine was examined in three groups of Sprague-Dawley rats (MFS, CS and CFE) obtained from different breeders and in Long-Evans rats (MLE) obtained from one of the same breeders. All rats responded with a rise in blood pressure to i.c.v. injection of neostigmine, although the CFE strain was 6-fold less sensitive to the drug than were the other strains.Prior i.c.v. injection of hemicholinium-3 (HC-3; 0.4 mug) reduced by more than 50% the pressor response in the two strains obtained from the same breeder (MFS and MLE) and caused an 1 1% reduction in the CS strain. In contrast, the pressor response in CFE rats was not affected by as much as 40mug of HC-3, although this dose decreased the response to neostigmine by 47-66% in the other three strains.
对从不同饲养者处获得的三组斯普拉格-道利大鼠（MFS、CS和CFE）以及从同一饲养者之一处获得的长-伊文斯大鼠（MLE），检测了脑室内（i.c.v.）注射新斯的明后的升压反应。所有大鼠对i.c.v.注射新斯的明均有血压升高反应，尽管CFE品系对该药物的敏感性比其他品系低6倍。预先i.c.v.注射3-羟基毒扁豆碱（HC-3；0.4微克）使来自同一饲养者的两个品系（MFS和MLE）的升压反应降低了50%以上，并使CS品系的升压反应降低了11%。相比之下，CFE大鼠的升压反应不受高达40微克HC-3的影响，尽管该剂量使其他三个品系对新斯的明的反应降低了47%-66%。
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