Ellingwood K E, Million R R
Cancer. 1979 Apr;43(4):1517-26. doi: 10.1002/1097-0142(197904)43:4<1517::aid-cncr2820430445>3.0.co;2-b.
During the period from October 1964 to September 1975, 32 patients were treated at the University of Florida for a variety of malignant tumors of the nasal cavity and ethmoid/sphenoid sinuses. All were treated with radical irradiation, 6091 to 7972 rad, in 6 to 9 weeks, cobalt-60. Pretreatment work-up revealed evidence of orbital invasion in 7 patients and involvement of the cranial contents, base of skull, or nasopharynx in an additional 15 patients. Local control was achieved in 95% of nasal cavity cases and 71% of ethmoid/sphenoid sinus cases at 2 years or more. The 5-year actuarial survival rate was 59%, and 5-year survival without evidence of disease was 50% (13/26). Patterns of extension in advanced lesions are clues to potential undetected extension in early cases which must be included in the treatment volume. Eye complications were minimal when it was possible to avoid treatment of the entire eye, but developed in all cases requiring treatment of the entire orbit. Acute and chronic complications involving the eye, ear, central nervous system, sinuses, and nose were reviewed and correlated with initial tumor extent, dose, and radiation treatment technique.
1964年10月至1975年9月期间，佛罗里达大学对32例鼻腔及筛窦/蝶窦恶性肿瘤患者进行了治疗。所有患者均接受了钴 - 60根治性放疗，剂量为6091至7972拉德，疗程6至9周。治疗前检查发现7例患者有眼眶侵犯，另有15例患者有颅内、颅底或鼻咽部受累。2年或更长时间后，鼻腔病例的局部控制率为95%，筛窦/蝶窦病例为71%。5年精算生存率为59%，无疾病证据的5年生存率为50%（13/26）。晚期病变的扩展模式提示早期病例可能存在未被发现的扩展，这些区域必须纳入治疗范围。若能避免对整个眼球进行治疗，眼部并发症极少，但在所有需要对整个眼眶进行治疗的病例中均出现了眼部并发症。对涉及眼睛、耳朵、中枢神经系统、鼻窦和鼻子的急慢性并发症进行了回顾，并与初始肿瘤范围、剂量和放射治疗技术进行了相关性分析。
