Mishkin S, Morris H P, Yalovsky M A, Narasimha Murthy P V
Cancer Res. 1979 Jul;39(7 Pt 1):2371-5.
The survival of Buffalo rats brearing Morris Hepatoma 7800 was increased significantly (23 to 31%) after induction of hypothyroidism by propylthiouracil (PTU) (0.1% in Purina rat chow) or 131I. The concentration of PTU used was in the optimal range as 0.03% PTU was less effective than 0.1%, while 0.4% PTU appeared to be toxic. Exogenous thyroxine (8 microgram/kg body weight) reversed the effects of PTU and actually shortened survival. Because food consumption and body weights of hypothyroid rats were decreased, the survival of pair-fed controls was studied and found to be the same as in untreated controls. We conclude that the hypothyroid state increases the survival of rats bearing Morris Hepatoma 7800. We have not yet been able to define any anatomical or biochemical parameters which may be responsible for this effect.
用丙硫氧嘧啶（PTU）（在普瑞纳大鼠饲料中含量为0.1%）或131I诱导布法罗大鼠发生甲状腺功能减退后，携带莫里斯肝癌7800的大鼠存活率显著提高（23%至31%）。所用PTU的浓度处于最佳范围，因为0.03%的PTU效果不如0.1%，而0.4%的PTU似乎具有毒性。外源性甲状腺素（8微克/千克体重）可逆转PTU的作用，实际上缩短了生存期。由于甲状腺功能减退大鼠的食物摄入量和体重下降，因此对成对喂食的对照组的生存期进行了研究，发现与未处理的对照组相同。我们得出结论，甲状腺功能减退状态可提高携带莫里斯肝癌7800大鼠的存活率。我们尚未能够确定任何可能导致这种效应的解剖学或生化参数。
