Mishkin S Y, Pollack R, Yalovsky M A, Morris H P, Mishkin S
Cancer Res. 1981 Aug;41(8):3040-5.
The local growth rate of Morris Hepatoma 44 (generation time, 6 months) was inhibited by 66 to 87%, and host survival was prolonged by 36 to 78% after the induction of hypothyroidism within 2 weeks of tumor implantation by propylthiouracil (0.1% in Purina chow), 131I(1 mCi/100 g body weight i.p.), or surgical thyroidectomy. In additional experiments, we studied the effects of inducing hypothyroidism (131I) at different stages in the natural history of Morris Hepatoma 44 on local and metastatic growth as well as on host survival. Induction of hypothyroidism within 2 weeks of tumor implantation (Group I) reduced local tumor growth as well as the number and size of pulmonary metastases, and prolonged survival by 70 to 80%. Induction of hypothyroidism at 6 weeks postimplantation when tumors were palpable (Group II) inhibited local growth by 39%, reduced the number and size of pulmonary metastases by approximately 80%, and prolonged host survival by 35%. Initiation of 131I treatment at 11 weeks when microscopic pulmonary emboli were present in most animals (Group III) reduced local growth by 19% and the number and size of pulmonary metastases by 72 and 50%, respectively. In this case, survival was prolonged by 17%. We conclude from these results that the local and metastatic growth of Morris hepatoma 44 as well as host survival are thyroid hormone-dependent processes. The mechanisms responsible for these observations remain to be explained.
通过丙硫氧嘧啶（普瑞纳饲料中含0.1%）、131I（1毫居里/100克体重，腹腔注射）或手术甲状腺切除在肿瘤植入后2周内诱发甲状腺功能减退后，莫里斯肝癌44（代时为6个月）的局部生长速率受到66%至87%的抑制，宿主存活期延长了36%至78%。在另外的实验中，我们研究了在莫里斯肝癌44自然病程的不同阶段诱发甲状腺功能减退（131I）对局部和转移生长以及宿主存活的影响。在肿瘤植入后2周内诱发甲状腺功能减退（第一组）可减少局部肿瘤生长以及肺转移灶的数量和大小，并使存活期延长70%至80%。在植入后6周肿瘤可触及之时诱发甲状腺功能减退（第二组）可使局部生长受到39%的抑制，肺转移灶的数量和大小减少约80%，并使宿主存活期延长35%。在11周时开始131I治疗，此时大多数动物出现微小肺栓塞（第三组），局部生长减少19%，肺转移灶的数量和大小分别减少72%和50%。在此情况下，存活期延长了17%。我们从这些结果得出结论，莫里斯肝癌44的局部和转移生长以及宿主存活是依赖甲状腺激素的过程。造成这些观察结果的机制尚待阐明。
