Aylsworth C F, Hodson C A, Berg G, Kledzik G, Meites J
Cancer Res. 1979 Jul;39(7 Pt 1):2436-9.
The effects of bilateral adrenalectomy or estradiol benzoate treatment were observed on growth of 7,12-dimethylbenz(a)-anthracene-induced mammary tumors during postpartum lactation. In the control and estradiol benzoate-treated postpartum lactating rats, the mammary tumors decreased approximately 40% in size by Day 5 postpartum and continued to regress to 50% of their average original diameter by Day 25 postpartum. Adrenalectomy on Day 3 postpartum prevented mammary tumor regression and resulted in renewed mammary tumor growth. By Day 10 postpartum, average mammary tumor size in the adrenalectomized rats reached prepartum diameter and continued to increase in size until Day 25. Although serum prolactin concentrations were significantly higher in the lactating rats with mammary tumors than in the nonlactating rats with mammary tumors, there were no significant differences in serum corticosterone values. Adrenalectomy resulted in a significant increase in serum prolactin levels and in a marked fall in serum corticosterone levels. It is concluded that in rats adrenocortical activity is primarily responsible for reduced mammary tumor growth during postpartum lactation.
观察双侧肾上腺切除术或苯甲酸雌二醇治疗对产后哺乳期7,12-二甲基苯并(a)蒽诱导的乳腺肿瘤生长的影响。在对照和苯甲酸雌二醇治疗的产后哺乳期大鼠中，乳腺肿瘤在产后第5天大小约减少40%，并在产后第25天继续消退至其平均原始直径的50%。产后第3天进行肾上腺切除术可阻止乳腺肿瘤消退，并导致乳腺肿瘤重新生长。到产后第10天，肾上腺切除大鼠的平均乳腺肿瘤大小达到产前直径，并继续增大直至第25天。尽管患有乳腺肿瘤的哺乳期大鼠血清催乳素浓度显著高于患有乳腺肿瘤的非哺乳期大鼠，但血清皮质酮值无显著差异。肾上腺切除术导致血清催乳素水平显著升高，血清皮质酮水平显著下降。得出的结论是，在大鼠中，肾上腺皮质活动是产后哺乳期乳腺肿瘤生长减少的主要原因。
