Chen H J, Bradley C J, Meites J
Cancer Res. 1976 Apr;36(4):1414-7.
The effect of adrenalectomy on 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth was studied in Sprague-Dawley female rats. Weekly measurements revealed that adrenalectomy significantly increased both mammary tumor size and number and elevated serum prolactin levels as compared to the intact controls. Daily injection of 1 mg hydrocortisone acetate into the intact 7,12-dimethylbenz(a)anthracene-tumor bearing rats did not significantly alter tumor size, number, or serum prolactin levels but, when injected into adrenalectomized rats, it prevented increased tumor growth and prolactin release. Daily injection of ovine prolactin and hydrocortisone suppressed endogenous prolactin release but significantly increased tumore size and number. Ergocornine, a prolactin-inhibiting drug, blocked adrenalectomy-induced tumor growth and partially blocked prolactin release. These results indicate that adrenalectomy in rats stimulates tumor growth by increasing prolactin release.
在斯普拉格-道利雌性大鼠中研究了肾上腺切除术对7,12-二甲基苯并(a)蒽诱导的乳腺肿瘤生长的影响。每周测量结果显示，与完整对照组相比，肾上腺切除术显著增加了乳腺肿瘤的大小和数量，并提高了血清催乳素水平。每天向完整的7,12-二甲基苯并(a)蒽荷瘤大鼠注射1mg醋酸氢化可的松，并未显著改变肿瘤大小、数量或血清催乳素水平，但注射到肾上腺切除的大鼠体内时，可阻止肿瘤生长增加和催乳素释放。每天注射羊催乳素和氢化可的松可抑制内源性催乳素释放，但显著增加肿瘤大小和数量。麦角隐亭，一种催乳素抑制药物，可阻断肾上腺切除诱导的肿瘤生长，并部分阻断催乳素释放。这些结果表明，大鼠肾上腺切除术通过增加催乳素释放来刺激肿瘤生长。
