源自人前列腺的癌胚抗原样物质
Carcinoembryonic antigen-like substance derived from human prostate.
作者信息
Williams R D, Bronson D L, Myl A D, Vandevoorde J P, Elliott A Y
出版信息
Cancer Res. 1979 Jul;39(7 Pt 1):2447-50.
Carcinoembryonic antigen-like substance, previously detected in large amounts in the medium from cultures of human prostatic epithelial cells, also is present in extracts of benign and malignant human prostate. By column chromatography, the prostate-derived carcinoembryonic antigen-like substance derived from cultured prostate is the same as that in tissue extracts and is distinctly different from colon-derived carcinoembryonic antigen. The molecular weight of prostate-derived carcinoembryonic antigen-like substance is estimated to be greater than 5 x 10(5). Prostate-derived carcinoembryonic antigen-like substance may be a prostate-specific substance.
癌胚抗原样物质先前在人前列腺上皮细胞培养物的培养基中大量检测到，在人良性和恶性前列腺提取物中也存在。通过柱色谱法，培养的前列腺来源的癌胚抗原样物质与组织提取物中的相同，且与结肠来源的癌胚抗原明显不同。前列腺来源的癌胚抗原样物质的分子量估计大于5×10⁵。前列腺来源的癌胚抗原样物质可能是一种前列腺特异性物质。
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