Jones L A, Bern H A
Cancer Res. 1979 Jul;39(7 Pt 1):2560-7.
Neonatal female BALB/cCrgl mice (mammary tumor virus unexpressed) were given a daily injection of estradiol and/or progesterone for 5 days, beginning within 36 hr after birth. About one-half of each group was ovariectomized when 40 days old, and all mice were killed when between 18.5 and 26 months of age. Neonatal progesterone leads to ovary-dependent persistent vaginal cornification and hyperplasia. In addition, 16 of the 24 progesterone-treated mice had genital tract lesions, and 4 of these showed predominantly glandular features. No such lesions were observed in either oil-treated or untreated mice. Lesions were also observed in both intact and ovariectomized mice treated with estrogen-progesterone combinations, but most of the lesions were not as severe as those seen in mice treated neonatally with progesterone alone, and they were predominantly squamous in appearance. Although mammary tumors were not observed in either the control or the neonatally steroid-treated intact mice, many in the latter groups possessed hyperplastic alveolar-like mammary nodules and other abnormalities.
新生雌性BALB/cCrgl小鼠（未表达乳腺肿瘤病毒）在出生后36小时内开始，每天注射雌二醇和/或孕酮，持续5天。每组约一半小鼠在40日龄时进行卵巢切除，所有小鼠在18.5至26月龄时处死。新生期孕酮会导致依赖卵巢的持续性阴道角化和增生。此外，在24只接受孕酮治疗的小鼠中，有16只出现生殖道病变，其中4只主要表现为腺体特征。在接受油处理或未处理的小鼠中未观察到此类病变。在用雌激素 - 孕酮组合治疗的完整和卵巢切除小鼠中也观察到病变，但大多数病变不如仅在新生期接受孕酮治疗的小鼠中严重，且它们主要表现为鳞状外观。尽管在对照或新生期接受类固醇治疗的完整小鼠中均未观察到乳腺肿瘤，但后一组中的许多小鼠具有增生性肺泡样乳腺结节和其他异常。
