Jones L A, Pacillas-Verjan R
Cancer Res. 1979 Jul;39(7 Pt 1):2591-4.
Twenty-eight cervicovaginal tracts from approximately 2-year-old female BALB/cCrgl mice neonatally exposed to ovarian steroids were cut into small segments and transplanted into syngeneic hosts. Within six months, six of 28 host animals developed tumors. Three tumors were from progesterone-exposed mice, two were from estrogen-exposed mice, and one was from estrogen-progesterone-exposed mice. These tumors have been maintained by serial transplantation for approximately two years. The progesterone-induced tumors are mixed tumors with both squamous cell and glandular components. The estrogen-induced tumors are squamous cell carcinomas. The estrogen-progesterone-induced tumor was originally a squamous cell carcinoma, which now resembles a basal cell carcinoma. The other tumors have maintained their original morphological characteristics. All tumors have proven to be hormone independent. No control cervicovaginal tracts developed tumors after transplantation, even after 24 months in the host animals.
将约2岁雌性BALB/cCrgl小鼠新生期暴露于卵巢类固醇的28条宫颈阴道组织切成小段，移植到同基因宿主中。六个月内，28只宿主动物中有6只发生肿瘤。3只肿瘤来自暴露于孕酮的小鼠，2只来自暴露于雌激素的小鼠，1只来自暴露于雌激素 - 孕酮的小鼠。这些肿瘤通过连续传代移植维持了约两年。孕酮诱导的肿瘤是具有鳞状细胞和腺性成分的混合肿瘤。雌激素诱导的肿瘤是鳞状细胞癌。雌激素 - 孕酮诱导的肿瘤最初是鳞状细胞癌，现在类似于基底细胞癌。其他肿瘤保持了其原始形态特征。所有肿瘤均已证明是激素非依赖性的。移植后，即使在宿主动物中放置24个月，对照宫颈阴道组织也未发生肿瘤。
