贝克抗叶酸剂联合5-氟尿嘧啶和甲基环己亚硝脲治疗转移性结直肠癌：西南肿瘤协作组研究（方案7764）
Baker's antifol in combination with 5-fluorouracil and methyl-CCNU in the treatment of metastatic colorectal cancer: a Southwest Oncology Group Study (Protocol 7764).
作者信息
Shaw M T, Bonnet J D, Wilson H, Heilbrun L K
出版信息
Cancer Treat Rep. 1980 Feb-Mar;64(2-3):247-50.
PMID:7407758
Abstract
Fifty-one previously untreated patients with metastatic colorectal cancer were treated with a combination of 5-fluorouracil, methyl-CCNU, and Baker's antifol. Six of 34 fully evaluable patients achieved a response. There were no apparent benefits obtained with this combination compared to treatment with 5-fluorouracil alone.
摘要
51例既往未接受过治疗的转移性结直肠癌患者接受了5-氟尿嘧啶、甲环亚硝脲和贝克抗叶酸剂联合治疗。34例可全面评估的患者中有6例获得缓解。与单独使用5-氟尿嘧啶治疗相比，这种联合治疗未显示出明显益处。
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