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贝克抗叶酸剂联合5-氟尿嘧啶和甲基环己亚硝脲治疗转移性结直肠癌：西南肿瘤协作组研究（方案7764）

Baker's antifol in combination with 5-fluorouracil and methyl-CCNU in the treatment of metastatic colorectal cancer: a Southwest Oncology Group Study (Protocol 7764).

作者信息

Shaw M T, Bonnet J D, Wilson H, Heilbrun L K

出版信息

Cancer Treat Rep. 1980 Feb-Mar;64(2-3):247-50.

PMID:7407758
Abstract

Fifty-one previously untreated patients with metastatic colorectal cancer were treated with a combination of 5-fluorouracil, methyl-CCNU, and Baker's antifol. Six of 34 fully evaluable patients achieved a response. There were no apparent benefits obtained with this combination compared to treatment with 5-fluorouracil alone.

摘要

51例既往未接受过治疗的转移性结直肠癌患者接受了5-氟尿嘧啶、甲环亚硝脲和贝克抗叶酸剂联合治疗。34例可全面评估的患者中有6例获得缓解。与单独使用5-氟尿嘧啶治疗相比，这种联合治疗未显示出明显益处。

相似文献

1
Baker's antifol in combination with 5-fluorouracil and methyl-CCNU in the treatment of metastatic colorectal cancer: a Southwest Oncology Group Study (Protocol 7764).贝克抗叶酸剂联合5-氟尿嘧啶和甲基环己亚硝脲治疗转移性结直肠癌：西南肿瘤协作组研究（方案7764）
Cancer Treat Rep. 1980 Feb-Mar;64(2-3):247-50.
2
Phase II study of 5-fluorouracil, methyl-CCNU, and daunorubicin in colorectal cancer: a Cancer and Leukemia Group B study.5-氟尿嘧啶、甲基环己亚硝脲和柔红霉素用于结直肠癌的II期研究：一项癌症与白血病B组研究
Cancer Treat Rep. 1979 Feb;63(2):215-7.
3
Treatment of advanced colorectal cancer with methyl-CCNU plus 5-day 5-fluorouracil infusion.甲基环己亚硝脲联合5天氟尿嘧啶输注治疗晚期结直肠癌。
Cancer Treat Rep. 1978 Oct;62(10):1521-5.
4
Combination chemotherapy in patients with advanced colorectal carcinoma previously treated with 5-FU.先前接受过5-氟尿嘧啶治疗的晚期结直肠癌患者的联合化疗
Cancer Treat Rep. 1982 Dec;66(12):2093-4.
5
5-Fluorouracil (5-FU), methyl-CCNU, and vincristine in the treatment of advanced colorectal cancer: phase II study utilizing weekly 5-FU.5-氟尿嘧啶（5-FU）、甲基环己亚硝脲及长春新碱治疗晚期结直肠癌：采用每周一次5-FU的II期研究
Cancer Treat Rep. 1976 Nov;60(11):1597-600.
6
Combination chemotherapy for advanced colorectal cancer with triazinate, ICRF-159, 5-FU, and methyl-CCNU.用三嗪酸酯、ICRF-159、5-氟尿嘧啶和甲基环己亚硝脲联合化疗晚期结直肠癌。
Cancer Treat Rep. 1980 Oct-Nov;64(10-11):1143-5.
7
Phase 2 study with Baker's Antifol in solid tumors.使用贝克氏抗叶酸剂治疗实体瘤的2期研究。
Cancer Res. 1977 Apr;37(4):980-3.
8
Phase II evaluation of diglycoaldehyde, VP-16-213, and the combination of methyl-CCNU and beta-2'-deoxythioguanosine in previously treated patients with colorectal cancer: an Eastern Cooperative Oncology Group study (EST-1275).双甘醇醛、依托泊苷（VP-16-213）以及甲环亚硝脲与β-2'-脱氧硫代鸟苷联合用药用于既往接受过治疗的结直肠癌患者的II期评估：一项东部肿瘤协作组研究（EST-1275）
Cancer Treat Rep. 1979 Aug;63(8):1355-7.
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Methyl-CCNU versus methyl-CCNU and 5-fluorouracil in carcinoma of the large bowel.甲基环己亚硝脲单药与甲基环己亚硝脲联合5-氟尿嘧啶治疗大肠癌的疗效比较
Cancer Treat Rep. 1977 Nov;61(8):1453-8.
10
Phase II trial of ftorafur with mitomycin C versus ftorafur with methyl-CCNU in untreated colorectal cancer.氟尿嘧啶与丝裂霉素C联合用药对比氟尿嘧啶与甲环亚硝脲联合用药治疗未经治疗的结直肠癌的II期试验。
Cancer Treat Rep. 1978 May;62(5):689-92.