Koppang N
Acta Vet Scand. 1974;15(4):533-43. doi: 10.1186/BF03547224.
Experimental feeding, dealing with long term ingestion of small daily doses of DMNA has clearly demonstrated the cumulative toxic effect of this compound in sheep. A threshold level, somewhere between 0.10 mg and 0.15 mg DMNA/kg body weight per day, can be defined below which no toxicity even in quite long-lasting feeding can be demonstrated. Above this level toxicity changes will develop, clinically in most cases, anatomically in all, if the exposure time is long enough. If the daily intake of DMNA is over this threshold level, 21–40 mg DMNA/kg body weight, it usually causes liver disease and death in sheep. Neoplastic lesions were not produced, the experimental period, however, was below the latency period for carcinogenesis.
实验性喂养，即让绵羊长期每日摄入小剂量的二甲基亚硝胺（DMNA），已清楚地证明了该化合物对绵羊的累积毒性作用。可以确定一个阈值水平，介于每天每千克体重0.10毫克至0.15毫克DMNA之间，低于此水平，即使进行相当长时间的喂养也不会显示出毒性。高于此水平，如果暴露时间足够长，在大多数情况下临床上会出现毒性变化，在所有情况下解剖学上都会出现毒性变化。如果DMNA的每日摄入量超过这个阈值水平，即每千克体重21 - 40毫克DMNA，通常会导致绵羊患肝病并死亡。然而，在实验期间并未产生肿瘤性病变，因为实验期低于致癌作用的潜伏期。
