Soback S
Acta Vet Scand. 1981;22(3-4):493-500. doi: 10.1186/BF03548674.
A method for testing the effect of sulfonamides on lactic acid bacteria was developed. Sulfadiazine was used as the inhibitory substance. In the study 3 lactic acid bacteria, Lactobacillus lactis, Lactobacillus helveticus and Streptococcus thermophilus, were used. Lactic acid production, pH and plate count were used as parameters when monitoring the effect of Sulfadiazine on the test organisms under anaerobic conditions in milk medium. A depressing effects due to Sulfadiazine on each of the test microbes could be demonstrated by all of the parameters used. Measurement of the inhibition in lactic acid production using Streptococcus thermophilus as test organism should be used when rapid determination of Sulfadiazine residues in milk is preferred.
开发了一种测试磺胺类药物对乳酸菌作用效果的方法。使用磺胺嘧啶作为抑制物质。在该研究中，使用了3种乳酸菌，即乳酸乳杆菌、瑞士乳杆菌和嗜热链球菌。在牛奶培养基中厌氧条件下监测磺胺嘧啶对受试微生物的作用时，将乳酸产量、pH值和平板计数用作参数。所使用的所有参数都能证明磺胺嘧啶对每种受试微生物都有抑制作用。当首选快速测定牛奶中磺胺嘧啶残留量时，应以嗜热链球菌作为受试微生物来测量乳酸产量的抑制情况。
