分子氧氧化亚铁过氧化物酶的动力学。一种末端氧化酶模型。
The kinetics of oxidation of ferroperoxidase by molecular oxygen. A model of a terminal oxidase.
作者信息
Phelps C F, Antonini E, Giacometti G, Brunori M
出版信息
Biochem J. 1974 Jul;141(1):265-72. doi: 10.1042/bj1410265.
Abstract
- The decay of oxyferroperoxidase to ferriperoxidase was studied by rapidly mixing solutions of ferroperoxidase with various amounts of oxygen and following the time-course of appearance of oxyferroperoxidase and its subsequent decay to ferriperoxidase by reaction with ferroperoxidase. 2. The scheme can be accommodated by and [Formula: see text] and occurs without detectable intermediates being observed in the millisecond time-range. 3. Analogue-computer simulation of the reaction is in agreement with the initial rate-limiting reaction being an intermolecular, not intramolecular, electron-donating process, and analysis of the data leads to quantitative values for the rate constants of the overall process. 4. The reaction of oxyferroperoxidase with ferroperoxidase is a model of a terminal oxidase, and the results are discussed in terms of the possible importance of this reaction in peroxidase function, and also in the light it throws on autoxidation of haem compounds.
摘要
- 通过将亚铁过氧化物酶溶液与不同量的氧气快速混合，并跟踪亚铁过氧化物酶与氧气反应生成氧合亚铁过氧化物酶及其随后衰变为高铁过氧化物酶的时间进程，研究了氧合亚铁过氧化物酶向高铁过氧化物酶的衰变。2. 该反应历程可以用[化学式：见原文]来解释，并且在毫秒时间范围内未观察到可检测的中间体。3. 该反应的模拟计算机模拟结果与初始速率限制反应是分子间而非分子内的电子供体过程一致，对数据的分析得出了整个过程速率常数的定量值。4. 氧合亚铁过氧化物酶与亚铁过氧化物酶的反应是末端氧化酶的一个模型，本文根据该反应在过氧化物酶功能中的可能重要性以及它对血红素化合物自氧化的启示来讨论结果。
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The kinetics of oxidation of ferroperoxidase by molecular oxygen. A model of a terminal oxidase.分子氧氧化亚铁过氧化物酶的动力学。一种末端氧化酶模型。
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