Bell C, Conway E L, Lang W J
Br J Pharmacol. 1974 Dec;52(4):591-5. doi: 10.1111/j.1476-5381.1974.tb09728.x.
1 Increases in renal blood flow were produced by intra-arterial injections of dopamine (5-50 mug) in anaesthetized dogs pretreated with alpha- and beta-adrenoceptor antagonists.2 Intra-arterial administration of ergometrine (0.5 mg) or apomorphine (1 mg) produced a depression of the renal dilator responses to dopamine, without affecting renal dilatations in response to intra-arterial acetylcholine (0.1-1 mug) or histamine (2-50 mug).3 The depression of dopamine responses lasted 10-15 min, and was greater with ergometrine than with apomorphine.4 It is concluded that both ergometrine and apomorphine can be used as specific blocking agents at vascular dopamine receptors. Ergometrine is the preferred drug for this purpose.
在预先用α和β肾上腺素能受体拮抗剂处理过的麻醉犬中，动脉内注射多巴胺（5 - 50微克）可使肾血流量增加。
动脉内给予麦角新碱（0.5毫克）或阿扑吗啡（1毫克）可使肾对多巴胺的扩张反应受到抑制，而不影响肾对动脉内给予乙酰胆碱（0.1 - 1微克）或组胺（2 - 50微克）的扩张反应。
多巴胺反应的抑制持续10 - 15分钟，麦角新碱引起的抑制比阿扑吗啡更明显。
得出的结论是，麦角新碱和阿扑吗啡都可作为血管多巴胺受体的特异性阻断剂。为此目的，麦角新碱是首选药物。
