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犬体内由β-肾上腺素能受体兴奋剂诱导的肾血管舒张是否通过多巴胺受体介导？

Is the renal vasodilatation induced by beta-adrenoceptor stimulants in the dog mediated through dopamine receptor?

作者信息

Bell C, Mya M K

出版信息

Experientia. 1977 May 15;33(5):638-9. doi: 10.1007/BF01946546.

DOI:10.1007/BF01946546
PMID:862800
Abstract

In chloralose-anaesthetized dogs the renal vasodilator effect of isoprenaline is depressed by blockade of either dopamine or beta-adrenoceptors but the renal vasodilator effect of dopamine is depressed only by blockade of dopamine receptors. This suggests that the vasodilatation induced by beta-stimulants within the canine kidney is due in part to activation of dopamine receptors.

摘要

在水合氯醛麻醉的犬中，异丙肾上腺素的肾血管舒张作用可因多巴胺受体或β-肾上腺素能受体的阻断而受到抑制，但多巴胺的肾血管舒张作用仅因多巴胺受体的阻断而受到抑制。这表明犬肾内β-兴奋剂诱导的血管舒张部分归因于多巴胺受体的激活。

相似文献

1
Is the renal vasodilatation induced by beta-adrenoceptor stimulants in the dog mediated through dopamine receptor?犬体内由β-肾上腺素能受体兴奋剂诱导的肾血管舒张是否通过多巴胺受体介导？
Experientia. 1977 May 15;33(5):638-9. doi: 10.1007/BF01946546.
2
Vascular dopamine receptors in the canine hindlimb.犬后肢的血管多巴胺受体
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3
Selective blockade of dopamine-induced vasodilation by ergonovine maleate in the vasculatures of dogs and rabbits.
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):243-56.
4
Ergometrine and apomorphine as selective antagonists of dopamine in the canine renal vasculature.麦角新碱和阿扑吗啡作为犬肾血管中多巴胺的选择性拮抗剂。
Br J Pharmacol. 1974 Dec;52(4):591-5. doi: 10.1111/j.1476-5381.1974.tb09728.x.
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Localization of vasodilator dopamine receptors in the canine hindlimb.犬后肢血管舒张性多巴胺受体的定位
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Effects of renal dopamine receptor and beta-adrenoreceptor blockade on rises in blood angiotensin after haemorrhage, renal ischaemia and frusemide diuresis in the dog.肾多巴胺受体和β-肾上腺素能受体阻断对犬出血、肾缺血和速尿利尿后血中血管紧张素升高的影响。
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The beta-adrenoceptor blocking properties of the alpha-methyl analogues of propranolol and practolol in the anaesthetized dog.普萘洛尔和普拉洛尔的α-甲基类似物在麻醉犬体内的β-肾上腺素能受体阻断特性
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[Direct renal action of isoprenaline and propranolol].[异丙肾上腺素和普萘洛尔对肾脏的直接作用]
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Downregulation of propranolol-sensitive beta-adrenoceptor signaling after inhibition of nitric oxide synthesis.一氧化氮合成受抑制后普萘洛尔敏感的β-肾上腺素能受体信号通路的下调
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引用本文的文献

1
Effect of isoprenaline on dopamine receptors in the rabbit isolated renal artery.
Experientia. 1981;37(8):889-90. doi: 10.1007/BF01985697.
2
Localization of vasodilator dopamine receptors in the canine hindlimb.犬后肢血管舒张性多巴胺受体的定位
Br J Pharmacol. 1978 Oct;64(2):253-7. doi: 10.1111/j.1476-5381.1978.tb17297.x.
3
Evidence for dopaminergic vasodilator innervation of the canine paw pad.犬爪垫多巴胺能血管舒张神经支配的证据。
Br J Pharmacol. 1979 Nov;67(3):337-43. doi: 10.1111/j.1476-5381.1979.tb08685.x.

本文引用的文献

1
Comparison of the effects of dopamine, isoproterenol, norepinephrine and bradykinin on canine renal and femoral blood flow.多巴胺、异丙肾上腺素、去甲肾上腺素和缓激肽对犬肾血流和股血流影响的比较。
J Pharmacol Exp Ther. 1966 Jan;151(1):23-31.
2
Attenuation of dopamine renal and mesenteric vasodilation by haloperidol: evidence for a specific dopamine receptor.氟哌啶醇对多巴胺引起的肾和肠系膜血管舒张的抑制作用：存在特异性多巴胺受体的证据。
J Pharmacol Exp Ther. 1969 Aug;168(2):303-9.
3
Effects of dopamine and isoproterenol on renin secretion in the dog.多巴胺和异丙肾上腺素对犬肾素分泌的影响。
Proc Soc Exp Biol Med. 1972 May;140(1):54-7. doi: 10.3181/00379727-140-36394.
4
Perspectives in adrenergic beta-receptor blockade.肾上腺素能β受体阻滞剂的展望
Clin Pharmacol Ther. 1969 May-Jun;10(3):292-306. doi: 10.1002/cpt1969103292.
5
Ergometrine and apomorphine as selective antagonists of dopamine in the canine renal vasculature.麦角新碱和阿扑吗啡作为犬肾血管中多巴胺的选择性拮抗剂。
Br J Pharmacol. 1974 Dec;52(4):591-5. doi: 10.1111/j.1476-5381.1974.tb09728.x.
6
Vascular dopamine receptors in the canine hindlimb.犬后肢的血管多巴胺受体
Br J Pharmacol. 1975 Oct;55(2):167-72. doi: 10.1111/j.1476-5381.1975.tb07625.x.
7
Effects of dopamine on isolated canine coronary arteries.多巴胺对离体犬冠状动脉的影响。
Cardiovasc Res. 1975 May;9(3):384-89. doi: 10.1093/cvr/9.3.384.