拟暗果蝇和威氏果蝇X染色体左臂和右臂上基因的剂量补偿
Dosage compensation of genes on the left and right arms of the X chromosome of Drosophila pseudoobscura and Drosophila willistoni.
作者信息
Abraham I, Lucchesi J C
出版信息
Genetics. 1974 Dec;78(4):1119-26. doi: 10.1093/genetics/78.4.1119.
Abstract
We have investigated the occurrence of dosage compensation in D. willistoni and D. pseudoobscura, two species whose X chromosome is metacentric with one arm homologous to the X and the other homologous to the left arm of chromosome 3 of D. melanogaster. Crude extracts were assayed for isocitrate dehydrogenase (XR), glucose-6-phosphate dehydrogenase (XL?), 6-phosphogluconate dehydrogenase (XL?), and alpha-glycerophosphate dehydrogenase (chromosome 2) in D. willistoni, and for esterase-5 (XR), glucose-6-phosphate dehydrogenase (XL?), 6-phosphogluconate dehydrogenase (XL?) and amylase (chromosome 3) in D. pseudoobscura. Our results indicate that a mechanism for dosage compensation is operative in both arms of the X chromosome of these two species.
摘要
我们研究了威氏果蝇（D. willistoni）和拟暗果蝇（D. pseudoobscura）中剂量补偿的发生情况，这两个物种的X染色体是中着丝粒染色体，其中一条臂与黑腹果蝇（D. melanogaster）的X染色体同源，另一条臂与黑腹果蝇的3号染色体左臂同源。对威氏果蝇的粗提物进行了异柠檬酸脱氢酶（XR）、葡萄糖-6-磷酸脱氢酶（XL?）、6-磷酸葡萄糖酸脱氢酶（XL?）和α-甘油磷酸脱氢酶（2号染色体）的检测，对拟暗果蝇的粗提物进行了酯酶-5（XR）、葡萄糖-6-磷酸脱氢酶（XL?）、6-磷酸葡萄糖酸脱氢酶（XL?）和淀粉酶（3号染色体）的检测。我们的结果表明，这两个物种X染色体的两条臂上都存在剂量补偿机制。
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