拟暗果蝇和威氏果蝇X染色体左臂和右臂上基因的剂量补偿
Dosage compensation of genes on the left and right arms of the X chromosome of Drosophila pseudoobscura and Drosophila willistoni.
作者信息
Abraham I, Lucchesi J C
出版信息
Genetics. 1974 Dec;78(4):1119-26. doi: 10.1093/genetics/78.4.1119.
Abstract
We have investigated the occurrence of dosage compensation in D. willistoni and D. pseudoobscura, two species whose X chromosome is metacentric with one arm homologous to the X and the other homologous to the left arm of chromosome 3 of D. melanogaster. Crude extracts were assayed for isocitrate dehydrogenase (XR), glucose-6-phosphate dehydrogenase (XL?), 6-phosphogluconate dehydrogenase (XL?), and alpha-glycerophosphate dehydrogenase (chromosome 2) in D. willistoni, and for esterase-5 (XR), glucose-6-phosphate dehydrogenase (XL?), 6-phosphogluconate dehydrogenase (XL?) and amylase (chromosome 3) in D. pseudoobscura. Our results indicate that a mechanism for dosage compensation is operative in both arms of the X chromosome of these two species.
摘要
我们研究了威氏果蝇（D. willistoni）和拟暗果蝇（D. pseudoobscura）中剂量补偿的发生情况，这两个物种的X染色体是中着丝粒染色体，其中一条臂与黑腹果蝇（D. melanogaster）的X染色体同源，另一条臂与黑腹果蝇的3号染色体左臂同源。对威氏果蝇的粗提物进行了异柠檬酸脱氢酶（XR）、葡萄糖-6-磷酸脱氢酶（XL?）、6-磷酸葡萄糖酸脱氢酶（XL?）和α-甘油磷酸脱氢酶（2号染色体）的检测，对拟暗果蝇的粗提物进行了酯酶-5（XR）、葡萄糖-6-磷酸脱氢酶（XL?）、6-磷酸葡萄糖酸脱氢酶（XL?）和淀粉酶（3号染色体）的检测。我们的结果表明，这两个物种X染色体的两条臂上都存在剂量补偿机制。
相似文献
1
Dosage compensation of genes on the left and right arms of the X chromosome of Drosophila pseudoobscura and Drosophila willistoni.拟暗果蝇和威氏果蝇X染色体左臂和右臂上基因的剂量补偿
Genetics. 1974 Dec;78(4):1119-26. doi: 10.1093/genetics/78.4.1119.
2
Regulation of gene function: a comparison of enzyme activity levels in relation to gene dosage in diploids and triploids of Drosophila melanogaster.基因功能的调控：黑腹果蝇二倍体和三倍体中酶活性水平与基因剂量关系的比较
Biochem Genet. 1973 May;9(1):41-51. doi: 10.1007/BF00485589.
3
A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura.一种研究自然种群基因杂合性的分子方法。I. 果蝇拟暗果蝇不同基因座上的等位基因数量。
Genetics. 1966 Aug;54(2):577-94. doi: 10.1093/genetics/54.2.577.
4
Gene dosage compensation in metafemales (3X;2A) of Drosophila.果蝇超雌体（3X；2A）中的基因剂量补偿。
Nature. 1974 Apr 12;248(449):564-7. doi: 10.1038/248564a0.
5
Segmental aneuploidy and enzyme activity as a method for cytogenetic localization in drosophila melanogaster.作为黑腹果蝇细胞遗传学定位方法的染色体节段非整倍性和酶活性
Genetics. 1974 Feb;76(2):301-9. doi: 10.1093/genetics/76.2.301.
6
Gene modulation in Drosophila: dosage compensation of Pgd+ and Zw+ genes.果蝇中的基因调控：Pgd +和Zw +基因的剂量补偿
Biochem Genet. 1973 Dec;10(4):319-31. doi: 10.1007/BF00485987.
7
Regulation of enzyme activities in Drosophila. I. The detection of regulatory loci by gene dosage responses.果蝇中酶活性的调控。I. 通过基因剂量反应检测调控位点。
Genet Res. 1974 Aug;24(1):59-72. doi: 10.1017/s001667230001507x.
8
Dosage compensation of sex-linked genes in Drosophila melanogaster. The activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in flies with normal and disturbed genetic balance.黑腹果蝇性连锁基因的剂量补偿。正常和遗传平衡受到干扰的果蝇中葡萄糖-6-磷酸脱氢酶和6-磷酸葡萄糖酸脱氢酶的活性。
Mol Gen Genet. 1973 Nov 12;126(3):233-45. doi: 10.1007/BF00267534.
9
Pentose phosphate pathway enzyme studies of the lz allele of Drosophila melanogaster.黑腹果蝇lz等位基因的磷酸戊糖途径酶研究
J Hered. 1967 Sep-Oct;58(5):243-5. doi: 10.1093/oxfordjournals.jhered.a107601.
10
Isozyme frequency patterns in Drosophila pavani associated with geographical and seasonal variables.果蝇帕瓦尼中与地理和季节变量相关的同工酶频率模式。
Genetics. 1972 Dec;72(4):721-31. doi: 10.1093/genetics/72.4.721.
引用本文的文献
1
Dosage Compensation in Drosophila-a Model for the Coordinate Regulation of Transcription.果蝇中的剂量补偿——转录协同调控的模型
Genetics. 2016 Oct;204(2):435-450. doi: 10.1534/genetics.115.185108.
2
The life cycle of Drosophila orphan genes.果蝇孤儿基因的生命周期。
Elife. 2014 Feb 19;3:e01311. doi: 10.7554/eLife.01311.
3
Dosage compensation regulatory proteins and the evolution of sex chromosomes in Drosophila.剂量补偿调节蛋白与果蝇性染色体的进化
Genetics. 1996 Oct;144(2):705-13. doi: 10.1093/genetics/144.2.705.
4
Evolution of dosage compensation.剂量补偿的进化。
Chromosome Res. 1996 Apr;4(3):185-90. doi: 10.1007/BF02254957.
5
Adenine phosphoribosyltransferase genes in two Drosophila species: dosage compensation, a nuclear matrix attachment site, and a novel intron position.两种果蝇中的腺嘌呤磷酸核糖转移酶基因：剂量补偿、一个核基质附着位点和一个新的内含子位置。
Mol Gen Genet. 1993 Apr;238(3):383-9. doi: 10.1007/BF00291997.
6
Autosomal dosage compensation Drosophila melanogaster strains trisomic for the left arm of chromosome 2.常染色体剂量补偿：2号染色体左臂三体的黑腹果蝇品系。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1200-4. doi: 10.1073/pnas.79.4.1200.
7
Dosage compensation of X-linked heat-shock puffs in Drosophila pseudoobscura.果蝇拟暗果蝇中X连锁热休克疏松区的剂量补偿
Chromosoma. 1980;76(3):245-54. doi: 10.1007/BF00327265.
8
(dC-dA)n.(dG-dT)n sequences have evolutionarily conserved chromosomal locations in Drosophila with implications for roles in chromosome structure and function.(dC-dA)n.(dG-dT)n序列在果蝇中具有进化上保守的染色体位置，这对其在染色体结构和功能中的作用具有重要意义。
EMBO J. 1987 Jun;6(6):1781-9. doi: 10.1002/j.1460-2075.1987.tb02431.x.
9
Nonrandom distribution of long mono- and dinucleotide repeats in Drosophila chromosomes: correlations with dosage compensation, heterochromatin, and recombination.果蝇染色体中长单核苷酸和二核苷酸重复序列的非随机分布：与剂量补偿、异染色质和重组的相关性。
Mol Cell Biol. 1989 Mar;9(3):1173-82. doi: 10.1128/mcb.9.3.1173-1182.1989.
10
Dosage compensation and dietary glucose repression of larval amylase activity in Drosophila miranda.米兰达果蝇幼虫淀粉酶活性的剂量补偿和膳食葡萄糖抑制
Biochem Genet. 1990 Dec;28(11-12):601-13. doi: 10.1007/BF00553953.
本文引用的文献
1
DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.圆盘电泳。II. 方法及其在人血清蛋白中的应用。
Ann N Y Acad Sci. 1964 Dec 28;121:404-27. doi: 10.1111/j.1749-6632.1964.tb14213.x.
2
DISC ELECTROPHORESIS. I. BACKGROUND AND THEORY.圆盘电泳。一、背景与理论。
Ann N Y Acad Sci. 1964 Dec 28;121:321-49. doi: 10.1111/j.1749-6632.1964.tb14207.x.
3
The obscura group of the genus Drosophila.果蝇属的暗色类群。
Adv Genet. 1955;7:47-92.
4
A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura.一种研究自然种群基因杂合性的分子方法。I. 果蝇拟暗果蝇不同基因座上的等位基因数量。
Genetics. 1966 Aug;54(2):577-94. doi: 10.1093/genetics/54.2.577.
5
A molecular approach to the study of genic heterozygosity in natural populations. 3. Direct evidence of coadaptation in gene arrangements of Drosophila.一种研究自然种群基因杂合性的分子方法。3. 果蝇基因排列中共适应的直接证据。
Proc Natl Acad Sci U S A. 1968 Feb;59(2):398-405. doi: 10.1073/pnas.59.2.398.
6
Location of enzyme loci in chromosomes of Drosophila willistoni.果蝇威氏果蝇染色体上酶基因座的定位。
Experientia. 1972 Mar 15;28(3):355-6. doi: 10.1007/BF01928737.
7
Regulation of gene function: a comparison of enzyme activity levels in relation to gene dosage in diploids and triploids of Drosophila melanogaster.基因功能的调控：黑腹果蝇二倍体和三倍体中酶活性水平与基因剂量关系的比较
Biochem Genet. 1973 May;9(1):41-51. doi: 10.1007/BF00485589.
Zotero 插件