Stephens R, Green J, Haycook W, Kilgore M
Clin Electroencephalogr. 1979 Jan;10(1):31-4. doi: 10.1177/155005947901000103.
Our findings in a relatively small series of cases seem to confirm a lack of statistically significant EEG changes when Carbidopa is combined with Levodopa in the therapy of patients with Parkinson's disease. There appears to be a slight increase in basic background frequency which was one of the earlier findings when Levodopa was first used clinically. From the literature surveyed there appears to be a definite lack of consistency in the effects of Levodopa therapy on the electroencephalogram and on the clinical status of the patients followed. We think this well may be explainable by the fact that no large study has been accomplished in which a neuroanatomical (pathological) correlation has been done with both the clinical and the EEG data. Neurological examination and the electroencephalogram are both clinical tools and have yet to be closely reviewed with the added parameter of neuro-pathologic investigation in this new day of therapy for Parkinson's disease.
我们在相对少量病例中的研究结果似乎证实，在帕金森病患者的治疗中，卡比多巴与左旋多巴联合使用时，脑电图（EEG）变化在统计学上无显著意义。基础背景频率似乎略有增加，这是左旋多巴首次临床应用时较早发现的结果之一。从所查阅的文献来看，左旋多巴治疗对脑电图以及所观察患者临床状况的影响显然缺乏一致性。我们认为，这很可能可以用以下事实来解释，即尚未完成一项将神经解剖学（病理学）与临床和脑电图数据进行关联的大型研究。神经学检查和脑电图都是临床工具，在帕金森病治疗的新时代，还需要结合神经病理学研究这一附加参数进行仔细审视。
