Lieberman A, Goodgold A, Jonas S, Leibowitz M
Neurology. 1975 Oct;25(10):911-6. doi: 10.1212/wnl.25.10.911.
A double-blind study comparing the effects of carbidopa and levodopa combined in a single tablet with levodopa alone was undertaken in 50 patients with Parkinson's disease. After 6 months, there was a statistically significant improvement over baseline in total score, rigidity, and tremor only in the patients randomized to carbidopa/levodopa. In addition, 40 percent of the patients treated with carbidopa/levodopa showed obvious clinical improvement (a greater than 50 percent reduction in their total score) over treatment with levodopa alone. However, after 2 years, only 20 percent continued to show this improvement. Nausea, vomiting, and anorexia developed in 56 percent of patients on levodopa but in only 27 percent of patients on carbidopa/levodopa. However, abnormal involuntary movements, observed in 48 percent of patients on levodopa, were present in 77 percent of patients on carbidopa/levodopa. Despite the increase in abnormal involuntary movements, carbidopa/levodopa is more effective than levodopa.
对50例帕金森病患者进行了一项双盲研究，比较了卡比多巴和左旋多巴复方单片与单用左旋多巴的效果。6个月后，仅随机分配接受卡比多巴/左旋多巴治疗的患者在总分、强直和震颤方面较基线有统计学显著改善。此外，接受卡比多巴/左旋多巴治疗的患者中有40%较单用左旋多巴治疗有明显临床改善（总分降低超过50%）。然而，2年后，只有20%的患者持续显示这种改善。左旋多巴治疗的患者中有56%出现恶心、呕吐和厌食，而卡比多巴/左旋多巴治疗的患者中只有27%出现这些症状。然而，左旋多巴治疗的患者中有48%出现异常不自主运动，卡比多巴/左旋多巴治疗的患者中有77%出现异常不自主运动。尽管异常不自主运动有所增加，但卡比多巴/左旋多巴比左旋多巴更有效。
