迷走神经刺激或注入乙酰胆碱后兔离体心脏中前列腺素的释放。
Release of prostaglandin from the rabbit isolated heart following vagal nerve stimulation or acetylcholine infusion.
作者信息
Junstad M, Wennmalm A
出版信息
Br J Pharmacol. 1974 Nov;52(3):375-9. doi: 10.1111/j.1476-5381.1974.tb08605.x.
Abstract
1 Rabbit hearts were perfused by the Langendorff technique. The lipid fraction in the perfusate from the heart was isolated and analysed for prostaglandins by thin layer chromatography and quantitative assay on the rat isolated stomach strip.2 Infusion of acetylcholine at a rate of 8 mug/min significantly increased the outflow of prostaglandins from the heart, from 1.8 to 6.2 ng/minute.3 Addition of atropine (1 mug/ml) to the perfusing medium completely abolished not only the mechanical response but also the increase in outflow of prostaglandins caused by infusion of acetylcholine.4 Bilateral stimulation of the parasympathetic nerves to the heart at 5 Hz also significantly increased the outflow of prostaglandins from the organ from 5.2 to 8.3 ng/minute.5 Both prostaglandin E(1) and E(2) were isolated from the lipid fraction of the perfusate.6 The role of prostaglandins in relation to autonomic neurotransmission in the heart is discussed.
摘要
采用Langendorff技术对兔心脏进行灌注。从心脏灌注液中分离脂质部分，并通过薄层色谱法和大鼠离体胃条定量测定法分析前列腺素。
以8微克/分钟的速率输注乙酰胆碱可显著增加心脏前列腺素的流出量，从1.8纳克/分钟增加至6.2纳克/分钟。
向灌注介质中加入阿托品（1微克/毫升）不仅完全消除了机械反应，还消除了因输注乙酰胆碱导致的前列腺素流出量增加。
以5赫兹频率双侧刺激心脏的副交感神经也可显著增加该器官前列腺素的流出量，从5.2纳克/分钟增加至8.3纳克/分钟。
从灌注液的脂质部分中分离出前列腺素E(1)和E(2)。
讨论了前列腺素在心脏自主神经传递中的作用。
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