Allen H D, Taussig L M, Gaines J A, Sahn D J, Goldberg S J
Chest. 1979 Apr;75(4):428-33. doi: 10.1378/chest.75.4.428.
In this echocardiographic study, assessment of the heart in children with cystic fibrosis has shown that changes occur in not only the right ventricle but also in the left ventricle and aorta, as compared with normal. Echocardiograms could be successfully performed in 34 of 37 patients. The thickness of the right ventricular anterior wall and the dimension of the right ventricular cavity were abnormal, even in patients with mild disease (National Institutes of Health [NIH] score for severity of disease of 85 or greater). Larger, older children with lower NIH score had disproportionately larger right ventricular anterior walls and cavities. The thickness of the septal wall, the thickness of the left ventricular posterior wall, and the aortic dimensions were increased in those with severe disease. The dimensions of the left ventricular cavity for the population were slightly but significantly smaller than normal in systole and in diastole throughout the course of the disease. This study demonstrates that echocardiography is an effective noninvasive means of assessing the long-term changes in children with cystic fibrosis. These changes occur in both sides of the heart and appear to worsen as the disease progresses.
在这项超声心动图研究中，对囊性纤维化患儿心脏的评估显示，与正常儿童相比，不仅右心室发生了变化，左心室和主动脉也出现了变化。37例患者中有34例成功进行了超声心动图检查。即使是病情较轻的患者（美国国立卫生研究院[NIH]疾病严重程度评分为85或更高），右心室前壁厚度和右心室腔大小也不正常。NIH评分较低的年龄较大的儿童，其右心室前壁和腔室异常增大。病情严重者的室间隔厚度、左心室后壁厚度和主动脉内径增加。在整个疾病过程中，该人群左心室腔在收缩期和舒张期的大小均略小于正常，但差异有统计学意义。这项研究表明，超声心动图是评估囊性纤维化患儿长期变化的一种有效的非侵入性方法。这些变化发生在心脏两侧，并且似乎随着疾病进展而恶化。
