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磺胺甲恶唑和磺胺嘧啶与甲氧苄啶联合用药的体外活性比较。

A comparison of the in vitro activities of sulfamethoxazole and sulfadiazine combinations with trimethoprim.

作者信息

Kuipers J S

出版信息

Chemotherapy. 1979;25(2):77-82. doi: 10.1159/000237826.

DOI:10.1159/000237826
PMID:446188
Abstract

The sensitivity of 125 strains of 13 species or genera of bacteria to sulfamethoxazole (SMZ), sulfadiazine (SDZ), trimethoprim (TMP), SMZ + TMP and SDZ + TMP was determined by means of trays. A comparison of all combinations of the different concentrations used shows that SMZ + TMP is in 1 case and SDZ + TMP in 4 cases more effective against the 13 species or genera tested than the other combinations. SMZ and SDZ were equally effective in synergistic action (as shown by the FIC indices) against the various kinds of bacteria.

摘要

采用平板法测定了13个种或属的125株细菌对磺胺甲恶唑(SMZ)、磺胺嘧啶(SDZ)、甲氧苄啶(TMP)、SMZ+TMP以及SDZ+TMP的敏感性。对所使用的不同浓度的所有组合进行比较表明,在针对所测试的13个种或属时,SMZ+TMP在1例中比其他组合更有效,SDZ+TMP在4例中比其他组合更有效。SMZ和SDZ在对各种细菌的协同作用中效果相同(如FIC指数所示)。

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Chemotherapy. 1979;25(2):77-82. doi: 10.1159/000237826.
2
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Antimicrob Agents Chemother. 1973 Nov;4(5):555-9. doi: 10.1128/AAC.4.5.555.

引用本文的文献

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Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.复方新诺明(甲氧苄啶-磺胺甲恶唑):抗菌活性及临床疗效的最新综述
Drugs. 1982 Dec;24(6):459-518. doi: 10.2165/00003495-198224060-00002.