Bismuth R, Jarlier V, Grosset J
Pathol Biol (Paris). 1983 May;31(5):429-33.
The synergy between sulfamethoxazole (SMZ) and trimethoprim (TMP) is studied on 91 methicillin sensitive S. aureus strains (methi.S) and 95 methicillin resistant S. aureus strains (methi.R). In methi.S strains, the MIC 90% of SMZ, TMP and SMZ + TMP (19 SMZ/1 TMP) is respectively 64, 0.5 and 2 mg/l. 98% of methi.S strains have a FIC index less than or equal to 0.6 and only one strain has a FIC index greater than or equal to 0.6. In methi.R strains, the MIC 90% of SMZ, TMP and SMZ + TMP is respectively 256, 0.5 and 4 mg/l. 77% of methi.R strains have a FIC index less than or equal to 0.6. The relationship between FIC index and disc diffusion method is studied: bridging inhibition zone between SMZ 200 mcg disc, and TMP 2.5 micrograms disc and difference of the inhibition diameter between SMZ + TMP disc and TMP 1.25 micrograms disc. There is a good correlation only in methi.S strains in the first method and in methi.S and methi.R strains in the second method.
对91株甲氧西林敏感金黄色葡萄球菌（methi.S）和95株甲氧西林耐药金黄色葡萄球菌（methi.R）研究了磺胺甲恶唑（SMZ）与甲氧苄啶（TMP）之间的协同作用。在methi.S菌株中，SMZ、TMP及SMZ + TMP（19SMZ/1TMP）的90% MIC分别为64、0.5和2mg/L。98%的methi.S菌株FIC指数小于或等于0.6，只有1株FIC指数大于或等于0.6。在methi.R菌株中，SMZ、TMP及SMZ + TMP的90% MIC分别为256、0.5和4mg/L。77%的methi.R菌株FIC指数小于或等于0.6。研究了FIC指数与纸片扩散法之间的关系：200μg SMZ纸片与2.5μg TMP纸片之间的抑菌圈搭桥，以及SMZ + TMP纸片与1.25μg TMP纸片之间抑菌直径的差异。仅在第一种方法的methi.S菌株以及第二种方法的methi.S和methi.R菌株中存在良好的相关性。
