Sidorenko G I, Tsulaya V R, Bonashevskaya T I, Shaĭpak V M
Environ Health Perspect. 1979 Jun;30:13-8. doi: 10.1289/ehp.793013.
The combined action of substances having a munidirectional toxic effect on the organism was studied for several typical chlorine derivatives of hydrocarbons (1,2-dichloropropane, 1,2,3,-trichloropropane, and perchloroethylene). Since a correct assessment of the combined action of substances is based on the comparison of the effect of mixed compounds and the effects observed for each component alone, research was conducted on each individual substances on the basis of the "concentration--time" relationship. The reaction of several mixtures of substances was also studied at various concentration levels, from high to low concentration levels of substances which are actually present in the atmosphere. Research result showed that the character of the mixture at both high and low levels of concentration was identical and approximate to the overall effects.
研究了几种典型的烃类氯衍生物（1,2 - 二氯丙烷、1,2,3 - 三氯丙烷和全氯乙烯）对生物体具有单向毒性作用的物质的联合作用。由于对物质联合作用的正确评估是基于混合化合物的作用与单独观察到的每种成分的作用的比较，因此基于“浓度 - 时间”关系对每种单独的物质进行了研究。还研究了几种物质混合物在从高到低的各种浓度水平下的反应，这些浓度水平实际上存在于大气中。研究结果表明，高浓度和低浓度水平下混合物的特征是相同的，并且近似于总体效应。
